T Improta

AstraZeneca (United Kingdom) — United Kingdom

Medicine · Health Sciences

9h-index2.0kcitations16works0.02yr avg
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Research Topics

Cytokine Signaling Pathways and Interactions(5), interferon and immune responses(4), Lung Cancer Treatments and Mutations(3), Hemoglobinopathies and Related Disorders(3), Galectins and Cancer Biology(3)

Publications16 total

P2.01-05 MAGELLAN: Phase 1B Study of Durvalumab with Novel Oncology Therapies, With/Without Chemotherapy, in Untreated Stage IV NSCLC
Journal of Thoracic Oncology·2019· 1 citedOpen Access
P2.01-18 ORION: Durvalumab+Olaparib Versus Durvalumab Alone as Maintenance Therapy in Stage IV Non-Small Cell Lung Cancer (NSCLC)
Journal of Thoracic Oncology·2019
ORION: A Phase 2, randomized, multicenter, double-blind study to assess efficacy and safety of durvalumab+olaparib vs durvalumab alone as maintenance therapy in Stage IV non-small cell lung cancer (NSCLC).
Journal of Clinical Oncology·2019· 4 cited
SUSCEPTIBILITY TO VIRUS INFECTION IS DETERMINED BY A STAT-MEDIATED RESPONSE TO THE AUTOCRINE EFFECT OF VIRUS-INDUCED TYPE I INTERFERON
Cytokine·1997· 15 cited
Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein.
Proceedings of the National Academy of Sciences·1994· 150 citedOpen Access
Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways.
The EMBO Journal·1993· 414 citedOpen Access
Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.
Proceedings of the National Academy of Sciences·1992· 664 cited
The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.
Proceedings of the National Academy of Sciences·1992· 533 cited
Interferon-γ Potentiates the Antiviral Activity and the Expression of Interferon-Stimulated Genes Induced by Interferon-α in U937 Cells
Journal of Interferon Research·1992· 45 cited
Transmembrane signaling by interferon alpha involves diacylglycerol production and activation of the epsilon isoform of protein kinase C in Daudi cells.
Proceedings of the National Academy of Sciences·1991· 89 citedOpen Access
Patterns of MHC Class II Molecules and mRNA Expression in Acute Myelogenous Leukemias
1989
IFN-γ facilitates NGF-induced neuronal differentiation in PC12 cells
Experimental Cell Research·1988· 45 cited
Serum lactate dehydrogenase isoenzyme pattern in acute transformation of chronic granulocytic leukemia.
PubMed·1986· 3 cited
Delta beta-thalassaemia in southern Italy: evidence for a single mutational event.
Journal of Medical Genetics·1984· 3 citedOpen Access
Sr-thalassaemia insouthern :(taly: evidence for asingle mutational event
1984
Hb F-Siena (α<sub>2</sub>Aγt<sub>2</sub>121 (Gh4) Glu→Lys). A New Fetal Hemoglobin Variant
Hemoglobin·1983· 18 cited

Frequent Co-authors

Christian Schindler(4), James Darnell(3), M Marinucci(3), N M Sposi(3), Xiuping Fu(2), George R. Stark(2), Ian M. Kerr(2), Lawrence M. Pfeffer(2), Richard Pine(2), Michelle Marcovitz(2), Kate DiPiazza(2), Mark C. Lanasa(2), Adele Giampaolo(2), M Calandrini(2), Marina Petrini(2), Y. Liu(2), R Aebersold(1), J E Darnell(1), Ruedi Aebersold(1), Mathias Müller(1)