James Darnell

University of North Carolina at Chapel Hill — United States

Medicine · Health Sciences

143h-index87.6kcitations567works1.02yr avg
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Research Topics

Cytokine Signaling Pathways and Interactions(106), RNA Research and Splicing(105), RNA and protein synthesis mechanisms(98), Virus-based gene therapy research(51), RNA modifications and cancer(51)

Publications567 total

Allele-specific depletion of GNAQQ209L via siRNA or an rAAV2-shRNA vector induces selective toxicity in GNAQQ209L uveal melanoma cells
Molecular Therapy Oncology·2025· 1 citedOpen Access
The JAK-STAT pathway at 30: Much learned, much more to do
Cell·2022· 597 citedOpen Access
Results from a black-box study for digital forensic examiners
2022· 8 citedOpen Access
Pre-mRNA processing includes <i>N</i><sup>6</sup> methylation of adenosine residues that are retained in mRNA exons and the fallacy of “RNA epigenetics”
RNA·2017· 78 citedOpen Access
m<sup>6</sup>A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover
Genes & Development·2017· 565 citedOpen Access
Performance Based Selection of RAP/RAS in Asphalt Mixtures
2015· 1 cited
Mutations in the linker domain affect phospho-STAT3 function and suggest targets for interrupting STAT3 activity
Proceedings of the National Academy of Sciences·2015· 56 citedOpen Access
A majority of m<sup>6</sup>A residues are in the last exons, allowing the potential for 3′ UTR regulation
Genes & Development·2015· 814 citedOpen Access
Reflections on the history of pre-mRNA processing and highlights of current knowledge: A unified picture
RNA·2013· 111 citedOpen Access
The JAK-STAT Pathway at Twenty
Immunity·2012· 1.5k citedOpen Access
The JAK-STAT pathway at 20
JAK-STAT·2012· 12 citedOpen Access
Pillars article: Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science. 1992. 257: 809-813.
PubMed·2011· 17 cited
Pillars Article: Interferon-Dependent Tyrosine Phosphorylation of a Latent Cytoplasmic Transcription Factor. <i>Science</i>. 1992. 257: 809–813
The Journal of Immunology·2011· 2 cited
STAT3, HIF-1, glucose addiction and Warburg effect
Aging·2010· 28 citedOpen Access
Serpin B3/B4, activated by STAT3, promote survival of squamous carcinoma cells
Biochemical and Biophysical Research Communications·2008· 29 citedOpen Access
STAT92E is a positive regulator of<i>Drosophila</i>inhibitor of apoptosis 1 (DIAP/1) and protects against radiation-induced apoptosis
Proceedings of the National Academy of Sciences·2008· 39 citedOpen Access
SnapShot: JAK-STAT Signaling
Cell·2007· 139 citedOpen Access
Amino Acid Residues Required for Physical and Cooperative Transcriptional Interaction of STAT3 and AP-1 Proteins c-Jun and c-Fos
Molecular and Cellular Biology·2007· 50 citedOpen Access
Interferon Research: Impact on Understanding Transcriptional Control
Current topics in microbiology and immunology·2007· 16 cited
Dephosphorylation of phosphotyrosine on STAT1 dimers requires extensive spatial reorientation of the monomers facilitated by the N-terminal domain
Genes & Development·2006· 160 citedOpen Access
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Frequent Co-authors

Curt M. Horvath(6), Ke Shuai(6), Vincent R. Prezioso(6), George R. Stark(4), David T. Levy(4), Jacqueline Bromberg(4), lan M. Kerr(3), Zhong Zhong(3), Christian Schindler(3), Edmund Lai(3), Yanxiang Zhao(2), Zilong Wen(2), George R. Stark(2), Frances M. Sladek(2), Klaus Scherrer(2), Chris Schindler(2), Shengdong Ke(2), John J. Fak(2), Cathrine Broberg Vågbø(2), Robert B. Darnell(2)