Shengdong Ke

Jackson Laboratory — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index2.4kcitations17works0.02yr avg
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Research Topics

RNA modifications and cancer(13), RNA Research and Splicing(11), RNA and protein synthesis mechanisms(7), Cancer-related gene regulation(4), Ubiquitin and proteasome pathways(2)

Publications17 total

Exon-intron boundary inhibits m6A deposition, enabling m6A distribution hallmark, longer mRNA half-life and flexible protein coding
Nature Communications·2023· 56 citedOpen Access
Pre-mRNA splicing inhibits m <sup>6</sup> A deposition, allowing longer mRNA half-life and flexible protein coding
2022Open Access
Deep learning modeling m6A deposition reveals the importance of downstream cis-element sequences
Nature Communications·2022· 33 citedOpen Access
m6A candidates predicted by iM6A
2021Open Access
m6A candidates predicted by iM6A
Zenodo (CERN European Organization for Nuclear Research)·2021Open Access
Saturation mutagenesis reveals manifold determinants of exon definition
Genome Research·2017· 75 citedOpen Access
Pre-mRNA processing includes <i>N</i><sup>6</sup> methylation of adenosine residues that are retained in mRNA exons and the fallacy of “RNA epigenetics”
RNA·2017· 78 citedOpen Access
m<sup>6</sup>A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover
Genes & Development·2017· 565 citedOpen Access
A majority of m<sup>6</sup>A residues are in the last exons, allowing the potential for 3′ UTR regulation
Genes & Development·2015· 814 citedOpen Access
Quantitative evaluation of all hexamers as exonic splicing elements
Genome Research·2011· 231 citedOpen Access
Context-dependent splicing regulation
RNA Biology·2011· 24 citedOpen Access
Intronic motif pairs cooperate across exons to promote pre-mRNA splicing
Genome biology·2010· 30 citedOpen Access
Splicing by cell type
Nature Biotechnology·2010· 3 citedOpen Access
Splicing of designer exons reveals unexpected complexity in pre-mRNA splicing
RNA·2009· 49 citedOpen Access
Activated Expression of an<i>Arabidopsis</i>HD-START Protein Confers Drought Tolerance with Improved Root System and Reduced Stomatal Density  
The Plant Cell·2008· 371 citedOpen Access
Positive selection acting on splicing motifs reflects compensatory evolution
Genome Research·2008· 53 citedOpen Access
Human pseudo exons, ~92000
Columbia Academic Commons (Columbia University)·2007Open Access

Frequent Co-authors

Lawrence A. Chasin(8), Zhiyuan Luo(5), James Darnell(3), Robert B. Darnell(3), Mauricio A. Arias(3), John J. Fak(2), Cathrine Broberg Vågbø(2), Sergey Kalachikov(2), James J. Russo(2), Jingyue Ju(2), Qilian Ma(2), Shan Sun(2), Ningning Li(2), Hongfeng Wang(2), Xiang H.-F. Zhang(2), Endalkachew A. Alemu(1), Claudia Mertens(1), Emily C. Gantman(1), Aldo Mele(1), Bhagwattie Haripal(1)