Lawrence A. Chasin

Columbia University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

46h-index8.4kcitations134works0.02yr avg
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Research Topics

RNA and protein synthesis mechanisms(47), RNA Research and Splicing(45), CRISPR and Genetic Engineering(24), RNA modifications and cancer(24), Viral Infectious Diseases and Gene Expression in Insects(18)

Publications134 total

Biotechnology and Bioengineering: Volume 119, Number 6, June 2022
Biotechnology and Bioengineering·2022Open Access
A multiauxotrophic CHO cell line for the rapid isolation of producers of diverse or high levels of recombinant proteins
Biotechnology and Bioengineering·2022· 11 cited
A possible role for weak RNA-protein interactions in exon recognition
2020
A doubly auxotrophic CHO‐K1 cell line for the production of recombinant monoclonal antibodies
Biotechnology and Bioengineering·2020· 17 cited
Saturation mutagenesis reveals manifold determinants of exon definition
Genome Research·2017· 75 citedOpen Access
Correction of point mutations at the endogenous locus of the dihydrofolate reductase gene using repair-PolyPurine Reverse Hoogsteen hairpins in mammalian cells
Biochemical Pharmacology·2016· 10 cited
CRISPR‐Cas targeted plasmid integration into mammalian cells via non‐homologous end joining
Biotechnology and Bioengineering·2015· 50 cited
Splicing of designer exons informs a biophysical model for exon definition
RNA·2014· 20 citedOpen Access
The isolation of CHO cells with a site conferring a high and reproducible transgene amplification rate
Journal of Biotechnology·2013· 10 cited
Faculty of 1000 evaluation for Predictive identification of exonic splicing enhancers in human genes.
2012
Quantitative evaluation of all hexamers as exonic splicing elements
Genome Research·2011· 231 citedOpen Access
Context-dependent splicing regulation
RNA Biology·2011· 24 citedOpen Access
Intronic motif pairs cooperate across exons to promote pre-mRNA splicing
Genome biology·2010· 30 citedOpen Access
Splicing by cell type
Nature Biotechnology·2010· 3 citedOpen Access
Gene amplification and vector engineering to achieve rapid and high-level therapeutic protein production using the Dhfr-based CHO cell selection system
Biotechnology Advances·2010· 99 cited
Splicing of designer exons reveals unexpected complexity in pre-mRNA splicing
RNA·2009· 49 citedOpen Access
Dynamic Regulation of Alternative Splicing by Silencers that Modulate 5′ Splice Site Competition
Cell·2008· 134 citedOpen Access
Faculty Opinions recommendation of Oriented scanning is the leading mechanism underlying 5' splice site selection in mammals.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2008Open Access
Faculty Opinions recommendation of Signal sequence- and translation-independent mRNA localization to the endoplasmic reticulum.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2008
Positive selection acting on splicing motifs reflects compensatory evolution
Genome Research·2008· 53 citedOpen Access
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Frequent Co-authors

Gail Urlaub(13), Xiang H.-F. Zhang(8), Pamela J. Mitchell(6), Adelaide M. Carothers(6), G Urlaub(4), Carlos J. Ciudad(4), Shengdong Ke(4), Emmanuel Käs(4), Dezider Grünberger(3), Ofra Kessler(3), Sergey Kalachikov(2), James J. Russo(2), Jingyue Ju(2), Jang H. Han(2), Lee Venolia(2), Maurice Rosenstraus(2), Mauricio A. Arias(2), Christina S. Leslie(2), Michael Wigler(1), Àngel Pellicer(1)