James Darnell

University of North Carolina at Chapel Hill — United States

Medicine · Health Sciences

143h-index87.6kcitations567works1.02yr avg
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Research Topics

Cytokine Signaling Pathways and Interactions(106), RNA Research and Splicing(105), RNA and protein synthesis mechanisms(98), Virus-based gene therapy research(51), RNA modifications and cancer(51)

Publications567 total

A Hopscotch-chromatin connection
Nature Genetics·2006· 7 cited
Cyclin D1 Is Transcriptionally Regulated by and Required for Transformation by Activated Signal Transducer and Activator of Transcription 3
Cancer Research·2006· 280 citedOpen Access
Validating Stat3 in cancer therapy
Nature Medicine·2005· 306 cited
Reduced STAT3 activity in mice mimics clinical disease syndromes
Biochemical and Biophysical Research Communications·2005· 17 cited
Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation–inactivation cycle
Proceedings of the National Academy of Sciences·2005· 165 citedOpen Access
Structural Bases of Unphosphorylated STAT1 Association and Receptor Binding
Molecular Cell·2005· 300 citedOpen Access
Transformation fingerprint: induced STAT3-C, v-Src and Ha-Ras cause small initial changes but similar established profiles in mRNA
Oncogene·2004· 24 cited
Essential Role of STAT3 in Postnatal Survival and Growth Revealed by Mice Lacking STAT3 Serine 727 Phosphorylation
Molecular and Cellular Biology·2003· 200 citedOpen Access
Distinct Transcriptional Activation Functions of STAT1α and STAT1β on DNA and Chromatin Templates
Journal of Biological Chemistry·2003· 67 citedOpen Access
Decay Rates of Human mRNAs: Correlation With Functional Characteristics and Sequence Attributes
Genome Research·2003· 633 citedOpen Access
A reinterpretation of the dimerization interface of the N‐terminal Domains of STATs
Protein Science·2003· 83 citedOpen Access
Introduction: A Brief History of the STATs and a Glance at the Future
2003· 1 cited
STAT3-dependent enhanceosome assembly and disassembly: synergy with GR for full transcriptional increase of the α2-macroglobulin gene
Genes & Development·2003· 116 citedOpen Access
Transcription factors as targets for cancer therapy
Nature reviews. Cancer·2002· 1.2k cited
The surprises of mammalian molecular cell biology
Nature Medicine·2002· 3 cited
Negative regulation of STAT92E by an N-terminally truncated STAT protein derived from an alternative promoter site
Genes & Development·2002· 45 citedOpen Access
STATs: transcriptional control and biological impact
Nature Reviews Molecular Cell Biology·2002· 3.2k cited
Requirement of Ca<sup>2+</sup>and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-γ
Proceedings of the National Academy of Sciences·2002· 125 citedOpen Access
Dissociation Time from DNA Determines Transcriptional Function in a STAT1 Linker Mutant
Journal of Biological Chemistry·2002· 87 citedOpen Access
Signal Transduction and the Control of Gene Expression
Science·2002· 709 cited
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Frequent Co-authors

Curt M. Horvath(6), Ke Shuai(6), Vincent R. Prezioso(6), George R. Stark(4), David T. Levy(4), Jacqueline Bromberg(4), lan M. Kerr(3), Zhong Zhong(3), Christian Schindler(3), Edmund Lai(3), Yanxiang Zhao(2), Zilong Wen(2), George R. Stark(2), Frances M. Sladek(2), Klaus Scherrer(2), Chris Schindler(2), Shengdong Ke(2), John J. Fak(2), Cathrine Broberg Vågbø(2), Robert B. Darnell(2)