Richard T. Pomerantz

Thomas Jefferson University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index2.5kcitations93works2.12yr avg
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Research Topics

DNA Repair Mechanisms(38), Click Chemistry and Applications(26), Histone Deacetylase Inhibitors Research(20), Cancer therapeutics and mechanisms(16), DNA and Nucleic Acid Chemistry(15)

Publications93 total

RTx-303, an Orally Bioavailable Polθ Polymerase Inhibitor That Potentiates PARP Inhibitors in BRCA Mutant Tumors
Journal of Medicinal Chemistry·2025· 2 citedOpen Access
Structural basis for Polθ-helicase DNA binding and microhomology-mediated end-joining
Nature Communications·2025· 9 citedOpen Access
Ezh2 and Intracellular Ca2+ Signals Interdependently Coordinate Gvhd and CAR T Cell Responses
Blood·2024
Template-Independent Enzymatic RNA Synthesis
2024· 1 citedOpen Access
DNA polymerase theta-mediated DNA repair is a functional dependency and therapeutic vulnerability in DNMT3A deficient leukemia cells
2024Open Access
Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM
Nature Communications·2024· 14 citedOpen Access
PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks
Nature Communications·2024· 19 citedOpen Access
Structural Basis for Polθ-Helicase DNA Binding and Microhomology-Mediated End-Joining
2024· 1 citedOpen Access
Figure S7 from 4′-Ethynyl-2′-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress
2024Open Access
Figure S3 from 4′-Ethynyl-2′-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress
2024Open Access
Figure S1 from 4′-Ethynyl-2′-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress
2024Open Access
Table S4 from 4′-Ethynyl-2′-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress
2024Open Access
Supplementary Methods from 4′-Ethynyl-2′-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress
2024Open Access
Figure S7 from 4′-Ethynyl-2′-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress
2024Open Access
Figure S4 from 4′-Ethynyl-2′-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress
2024Open Access
Figure S4 from 4′-Ethynyl-2′-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress
2024Open Access
Figure S2 from 4′-Ethynyl-2′-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress
2024Open Access
Data from 4′-Ethynyl-2′-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress
2024Open Access
Figure S8 from 4′-Ethynyl-2′-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress
2024Open Access
Figure S1 from 4′-Ethynyl-2′-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress
2024Open Access
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Frequent Co-authors

Tatiana Kent(24), Gurushankar Chandramouly(16), Tomasz Skórski(14), Timur Rusanov(10), Mike O’Donnell(9), Ekaterina Kashkina(8), Trung Hoàng(8), Xiaojiang S. Chen(8), Leonid Minakhin(7), Wayne E. Childers(7), Shane McDevitt(6), Nikita Borisonnik(6), Katherine Sullivan-Reed(6), Marissa L. Calbert(6), Neil Johnson(6), Ahmet Y. Ozdemir(5), John J. Krais(5), Umeshkumar Vekariya(5), Jessica Atkins(5), Margaret Nieborowska-Skorska(5)