Erald Shehu

Medicine · Health Sciences

6h-index172citations12works6.02yr avg
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Research Topics

Lysosomal Storage Disorders Research(4), Ubiquitin and proteasome pathways(3), CAR-T cell therapy research(3), Transgenic Plants and Applications(3), CRISPR and Genetic Engineering(2)

Publications12 total

FLT201, a novel liver-directed AAV gene therapy candidate for Gaucher disease type 1
Molecular Therapy·2025· 6 citedOpen Access
Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays
Scientific Reports·2022· 8 citedOpen Access
Differences in wild-type– and R338L-tenase complex formation are at the root of R338L-factor IX assay discrepancies
Blood Advances·2022· 13 citedOpen Access
Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1
Bioorganic & Medicinal Chemistry Letters·2021· 7 citedOpen Access
Development of a GLA nAb assay with a fully-human, neutralizing IgG4 positive control to characterize antibody response in Fabry disease patients
Molecular Genetics and Metabolism·2021
FLT201: An AAV-mediated gene therapy for type 1 Gaucher disease designed to target difficult to reach tissues
Molecular Genetics and Metabolism·2021· 3 cited
Generation of β-Glucocerebrosidase variants with increased half-life in human plasma for liver directed AAV gene therapy aimed at the treatment of Gaucher disease type 1
Molecular Genetics and Metabolism·2021· 2 cited
Achieving <i>In Vivo</i> Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders
Journal of Medicinal Chemistry·2020· 72 citedOpen Access
Design and Characterization of FLT210, a Potent Next Generation AAV-hFVIII Vector Candidate
Blood·2019
C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays
European Journal of Medicinal Chemistry·2019· 17 citedOpen Access
<i>Anterior gradient 2</i> and <i>3</i> – two prototype androgen‐responsive genes transcriptionally upregulated by androgens and by oestrogens in prostate cancer cells
FEBS Journal·2013· 44 cited
The expression and function of human Anterior Gradient Homolog 3 in Prostate Cancer
Repository KITopen (Karlsruhe Institute of Technology)·2013Open Access

Frequent Co-authors

Romuald Corbau(6), Angela Hayes(4), Rosemary Burke(4), Florence I. Raynaud(4), Fabrizio Comper(4), Clément Cocita(4), Elisa Chisari(4), Jalpa Pandya(4), Samantha Correia(4), Rose Sheridan(4), Olivier A. Pierrat(3), Yann‐Vaï Le Bihan(3), Craig McAndrew(3), Rob L. M. van Montfort(3), Olivia W. Rossanese(3), Jonathan H. Foley(3), Amit C. Nathwani(3), Carlos J. Miranda(3), Jey M Jeyakumar(3), Emmaline Stotter(3)