Leanne L. Cribbs

Loyola University Chicago — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

41h-index7.8kcitations93works0.02yr avg
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Research Topics

Ion channel regulation and function(73), Cardiac electrophysiology and arrhythmias(49), Neuroscience and Neuropharmacology Research(22), Neuroscience and Neural Engineering(13), Nicotinic Acetylcholine Receptors Study(11)

Publications93 total

Heteromeric Channels Formed From Alternating Kv7.4 and Kv7.5 α-Subunits Display Biophysical, Regulatory, and Pharmacological Characteristics of Smooth Muscle M-Currents
Frontiers in Physiology·2020· 6 citedOpen Access
A link between the inflammatory mediator interleukin‐13, the transcriptional repressor REST, the <i>KCNQ5</i> gene, and Kv7.5 potassium channel function in vascular smooth muscle cells
The FASEB Journal·2020
Structural Determinants of Kv7.5 Potassium Channels That Confer Changes in Phosphatidylinositol 4,5-Bisphosphate (PIP2) Affinity and Signaling Sensitivities in Smooth Muscle Cells
Molecular Pharmacology·2019· 4 citedOpen Access
Novel Inflammatory Signaling via Interleukin‐13 Decreases Potassium Channel Expression and Increases Vascular Smooth Muscle Excitability
The FASEB Journal·2019
Mechanisms of PKA-Dependent Potentiation of Kv7.5 Channel Activity in Human Airway Smooth Muscle Cells
International Journal of Molecular Sciences·2018· 19 citedOpen Access
Distinct regulatory domains on the N‐ and C‐termini of Kv7.4 and Kv7.5 contribute to both their voltage‐dependence of activation and their responses to PKA and PKC.
The FASEB Journal·2018
Chimeric Kv7.4 Channel with Amino-Terminus of Kv7.5 Has Putative Protein Kinase a Phosphorylation Site and is Sufficient to Confer Partial Sensitivity to Cyclic Adenosine Monophosphate/Protein Kinase a (cAMP/PKA) Pathway
Biophysical Journal·2018Open Access
Novel inflammatory mechanisms in the regulation of airway hyperresponsiveness: regulation of airway smooth muscle Kv7 channel expression by REST.
The FASEB Journal·2017
PKC-dependent regulation of Kv7.5 channels by the bronchoconstrictor histamine in human airway smooth muscle cells
American Journal of Physiology-Lung Cellular and Molecular Physiology·2017· 23 cited
Protein Kinase A-Dependent Phosphorylation Modulates the Affinity of Kv7.5 Potassium Channels to Phosphatidylinositol 4,5-Bisphosphate to Enhance Potassium Conductance
Biophysical Journal·2017Open Access
Kv7.5 Potassium Channel Subunits are the Primary Target for PKA-Dependent Enhancement of Vascular Smooth Muscle Kv7 Currents
Biophysical Journal·2016Open Access
Kv7.5 Potassium Channel Subunits Are the Primary Targets for PKA-Dependent Enhancement of Vascular Smooth Muscle Kv7 Currents
Molecular Pharmacology·2015· 60 citedOpen Access
Differential Activation of Vascular Smooth Muscle Kv7.4, Kv7.5, and Kv7.4/7.5 Channels by ML213 and ICA-069673
Molecular Pharmacology·2014· 51 citedOpen Access
Down-regulation of endogenous KLHL1 decreases voltage-gated calcium current density
Cell Calcium·2014· 20 cited
KCNQ (Kv7) potassium channel activators as bronchodilators: combination with a β<sub>2</sub>-adrenergic agonist enhances relaxation of rat airways
American Journal of Physiology-Lung Cellular and Molecular Physiology·2014· 25 citedOpen Access
Differential Protein Kinase C-dependent Modulation of Kv7.4 and Kv7.5 Subunits of Vascular Kv7 Channels
Journal of Biological Chemistry·2013· 71 citedOpen Access
The Kelch‐Like 1 Actin Binding Protein Modulates Neuronal Voltage Gated Calcium Channels
The FASEB Journal·2013· 1 cited
Elimination of the Actin-Binding Domain in Kelch-Like 1 Protein Induces T-Type Calcium Channel Modulation Only in the Presence of Action Potential Waveforms
Journal of Signal Transduction·2012· 5 citedOpen Access
Abstract P222: T-Type Calcium Channels Regulate NFAT Signaling in Cardiomyocytes and Are Expressed in Chronic Hypoxic Right Ventricle
Circulation Research·2011
Kv7 potassium channels in airway smooth muscle cells: signal transduction intermediates and pharmacological targets for bronchodilator therapy
American Journal of Physiology-Lung Cellular and Molecular Physiology·2011· 57 citedOpen Access
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Frequent Co-authors

Edward Perez‐Reyes(14), Kenneth L. Byron(13), Lioubov I. Brueggemann(11), Jung‐Ha Lee(9), Asif N. Daud(6), Jonathan Satin(6), Alexander R Mackie(5), Bharath K. Mani(5), R. B. Rogart(3), Edmund M. Talley(2), Douglas A. Bayliss(2), Antonio E. Lacerda(2), J. Elaine Barclay(2), Magali Williamson(2), Margaret Fox(2), Michele Rees(2), Juan Carlos Gómora(2), Alexei Pereverzev(2), Toni Schneider(2), Harry A. Fozzard(2)