Bert Spenkelink

Wageningen University & Research — Netherlands

Biochemistry, Genetics and Molecular Biology · Life Sciences

21h-index1.6kcitations42works0.72yr avg
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Research Topics

Carcinogens and Genotoxicity Assessment(11), Pharmacogenetics and Drug Metabolism(7), Environmental Toxicology and Ecotoxicology(7), Effects and risks of endocrine disrupting chemicals(7), Toxic Organic Pollutants Impact(4)

Publications42 total

MIND: a proposed strategic and collaborative platform for advancing chemical environmental risk assessment
Environmental Sciences Europe·2026Open Access
First exploration of currently used pesticides in garden dormouse in the Netherlands
2025Open Access
Species specific kinetics of imidacloprid and carbendazim in mouse and rat and consequences for biomonitoring
Computational Toxicology·2024· 2 citedOpen Access
Use of Physiologically Based Pharmacokinetic Modeling to Predict Human Gut Microbial Conversion of Daidzein to S-Equol
Journal of Agricultural and Food Chemistry·2021· 25 citedOpen Access
Physiologically based kinetic modelling based prediction of in vivo rat and human acetylcholinesterase (AChE) inhibition upon exposure to diazinon
Archives of Toxicology·2021· 18 citedOpen Access
Defining in vivo dose‐response curves for kidney DNA adduct formation of aristolochic acid I in rat, mouse and human by an in vitro and physiologically based kinetic modeling approach
Journal of Applied Toxicology·2020· 8 citedOpen Access
Induction of peroxisome proliferator activated receptor γ (PPARγ) mediated gene expression and inhibition of induced nitric oxide production by Maerua subcordata (Gilg) DeWolf
BMC Complementary Medicine and Therapies·2020· 11 citedOpen Access
Front Cover: Use of Physiologically Based Kinetic Modeling to Predict Rat Gut Microbial Metabolism of the Isoflavone Daidzein to <i>S</i>‐Equol and Its Consequences for ERα Activation
Molecular Nutrition & Food Research·2020· 2 cited
Microfluidic chip for culturing intestinal epithelial cell layers: Characterization and comparison of drug transport between dynamic and static models
Toxicology in Vitro·2020· 72 citedOpen Access
Use of Physiologically Based Kinetic Modeling to Predict Rat Gut Microbial Metabolism of the Isoflavone Daidzein to <i>S</i>‐Equol and Its Consequences for ERα Activation
Molecular Nutrition & Food Research·2020· 26 citedOpen Access
The role of metabolism in the developmental toxicity of polycyclic aromatic hydrocarbon‐containing extracts of petroleum substances
Journal of Applied Toxicology·2019· 15 citedOpen Access
Physiologically Based Kinetic Modeling-Facilitated Reverse Dosimetry to Predict In Vivo Red Blood Cell Acetylcholinesterase Inhibition Following Exposure to Chlorpyrifos in the Caucasian and Chinese Population
Toxicological Sciences·2019· 19 citedOpen Access
Hazard assessment of Maerua subcordata (Gilg) DeWolf. for selected endpoints using a battery of in vitro tests
Journal of Ethnopharmacology·2019· 34 citedOpen Access
Effects of Maerua subcordata (Gilg) DeWolf on electrophile-responsive element (EpRE)-mediated gene expression in vitro
PLoS ONE·2019· 7 citedOpen Access
Development of a Combined In Vitro Physiologically Based Kinetic (PBK) and Monte Carlo Modelling Approach to Predict Interindividual Human Variation in Phenol-Induced Developmental Toxicity
Toxicological Sciences·2017· 26 citedOpen Access
Study on inter-ethnic human differences in bioactivation and detoxification of estragole using physiologically based kinetic modeling
Archives of Toxicology·2017· 14 citedOpen Access
Integrating in vitro data and physiologically based kinetic (PBK) modelling to assess the in vivo potential developmental toxicity of a series of phenols
Archives of Toxicology·2016· 65 citedOpen Access
Evaluation of the interindividual human variation in bioactivation of methyleugenol using physiologically based kinetic modeling and Monte Carlo simulations
Toxicology and Applied Pharmacology·2014· 16 citedOpen Access
Conversion of major soy isoflavone glucosides and aglycones in in vitro intestinal models
Molecular Nutrition & Food Research·2013· 58 citedOpen Access
Combining in vitro embryotoxicity data with physiologically based kinetic (PBK) modelling to define in vivo dose–response curves for developmental toxicity of phenol in rat and human
Archives of Toxicology·2013· 80 cited
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Frequent Co-authors

Ivonne M.C.M. Rietjens(28), Ans Punt(11), Peter J. van Bladeren(9), Sebastiaan Wesseling(7), Laura de Haan(6), G.M. Alink(6), Abraham Brouwer(5), Marelle G. Boersma(4), Marije Strikwold(4), R.A. Woutersen(4), Rungnapa Boonpawa(4), Martin van den Berg(3), Bart L.H.J. Craane(3), Theo L. Sinnige(3), Ineke J. Lutke-Schipholt(3), Jacques Vervoort(3), Ala’ Ali Ahmad Al-Subeihi(3), Mebrahtom Gebrelibanos Hiben(3), Lenny Kamelia(3), Qianrui Wang(3)