Alexander F. A. Keszei

University Health Network — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index1.5kcitations40works5.62yr avg
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Research Topics

RNA modifications and cancer(11), Ubiquitin and proteasome pathways(10), interferon and immune responses(9), RNA and protein synthesis mechanisms(7), Glycosylation and Glycoproteins Research(5)

Publications40 total

Allosteric regulation of fungal fatty acid synthesis
Structure·2025
Author Correction: Structures of KEOPS bound to tRNA reveal functional roles of the kinase Bud32
Nature Communications·2025Open Access
Abstract 5425: Human mitochondrial ClpXP protease degrades serine phosphorylated substrates
Cancer Research·2025
Cryo-EM of AKAP350/AKAP9 Reveals Fibrillar Clusters and an Association With DNA
Journal of Molecular Biology·2025
Lipid-siRNA Organization Modulates the Intracellular Dynamics of Lipid Nanoparticles
Journal of the American Chemical Society·2025· 25 citedOpen Access
Serine phosphorylation facilitates protein degradation by the human mitochondrial ClpXP protease
Proceedings of the National Academy of Sciences·2025· 5 citedOpen Access
Structures of KEOPS bound to tRNA reveal functional roles of the kinase Bud32
Nature Communications·2024· 2 citedOpen Access
Unveiling the structural proteome of an Alzheimer’s disease rat brain model
Structure·2024
FAM72A degrades UNG2 through the GID/CTLH complex to promote mutagenic repair during antibody maturation
Nature Communications·2024· 16 citedOpen Access
Unveiling the Structural Proteome of an Alzheimer’s Disease Rat Brain Model
2024Open Access
Cryo-EM of AKAP350 reveals fibrillar clusters and a potential association with DNA
2024Open Access
Structure and dynamics of a pentameric KCTD5/CUL3/Gβγ E3 ubiquitin ligase complex
Proceedings of the National Academy of Sciences·2024· 13 citedOpen Access
The HisRS-like domain of GCN2 is a pseudoenzyme that can bind uncharged tRNA
Structure·2024· 13 citedOpen Access
Direct structural analysis of a single acyl carrier protein domain in fatty acid synthase from the fungus Saccharomyces cerevisiae
Communications Biology·2024· 5 citedOpen Access
Structure and dynamics of a pentameric KCTD5/Cullin3/Gβγ E3 ubiquitin ligase complex
2023· 5 citedOpen Access
Atomic model for core modifying region of human fatty acid synthase in complex with Denifanstat
Nature Communications·2023· 20 citedOpen Access
Cryo-EM structure of an active bacterial TIR–STING filament complex
Nature·2022· 114 citedOpen Access
Structural insights into metazoan pretargeting GET complexes
Nature Structural & Molecular Biology·2021· 14 citedOpen Access
Cyclic CMP and cyclic UMP mediate bacterial immunity against phages
Cell·2021· 268 citedOpen Access
Discovery of C13-Aminobenzoyl Cycloheximide Derivatives that Potently Inhibit Translation Elongation
Journal of the American Chemical Society·2021· 13 citedOpen Access
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Frequent Co-authors

Mohammad T. Mazhab‐Jafari(16), Sichen Shao(13), Frank Sicheri(12), Benjamin R. Morehouse(11), Philip J. Kranzusch(11), B. Lowey(9), Adi Millman(7), Rotem Sorek(7), Apurva A. Govande(6), Gal Ofir(6), S. M. Naimul Hasan(6), David L. Dai(5), Elton Zeqiraj(4), Mike Tyers(4), Derek F. Ceccarelli(4), Neil C. Pomroy(4), Gilbert G. Privé(4), Brian Raught(4), Elnaz Khalili Samani(4), Sadie P. Antine(3)