John R. Engen

Northeastern University — United States

Chemistry · Physical Sciences

64h-index16.9kcitations297works7.52yr avg
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Research Topics

Mass Spectrometry Techniques and Applications(70), Protein Structure and Dynamics(41), Analytical Chemistry and Chromatography(41), Protein Kinase Regulation and GTPase Signaling(38), Enzyme Structure and Function(30)

Publications297 total

Inhibition of oligomeric BAX by an anti-apoptotic dimer
Cell·2025· 1 cited
Rigorous Analysis of Multimodal HDX-MS Spectra
Journal of the American Society for Mass Spectrometry·2025· 17 cited
Author response: Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia
2024Open Access
An SH3-binding allosteric modulator stabilizes the global conformation of the AML-associated Src-family kinase, Hck
Journal of Biological Chemistry·2024· 1 citedOpen Access
Dynamic conformational equilibria in the active states of KRAS and NRAS
RSC Chemical Biology·2024· 16 citedOpen Access
Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia
eLife·2024Open Access
Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia
2024Open Access
Author response: Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia
2024Open Access
An SH3-binding allosteric modulator stabilizes the global conformation of the AML-associated Src-family kinase, Hck
2024· 1 citedOpen Access
Resolving chaperone-assisted protein folding on the ribosome at the peptide level
Nature Structural & Molecular Biology·2024· 31 citedOpen Access
The serine phosphorylations in the IRS-1 PIR domain abrogate IRS-1 and IR interaction
Proceedings of the National Academy of Sciences·2024· 24 citedOpen Access
Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia
eLife·2024· 7 citedOpen Access
Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia
2024· 1 citedOpen Access
Small-molecule allosteric modulators of the AML-associated Src-family kinase, Hck
Biophysical Journal·2024Open Access
Covalent inhibition of pro-apoptotic BAX
Nature Chemical Biology·2024· 22 citedOpen Access
Author Response: Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states
2024Open Access
Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states
eLife·2024· 1 citedOpen Access
Native Capillary Electrophoresis–Mass Spectrometry of Near 1 MDa Non‐Covalent GroEL/GroES/Substrate Protein Complexes
Advanced Science·2024· 13 citedOpen Access
Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia
2023· 2 citedOpen Access
Reviewer #2 (Public Review): Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states
2023Open Access
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Frequent Co-authors

Roxana E. Iacob(16), Thomas E. Wales(13), Kasper D. Rand(6), Nathanael S. Gray(5), Damian J. Houde(5), Steven A. Berkowitz(5), Thomas E. Smithgall(5), David D. Weis(4), Scott B. Ficarro(4), Jarrod A. Marto(4), Miklós Guttman(3), Pasi A. Jänne(2), George M. Bou-Assaf(2), Jianming Zhang(2), Taebo Sim(2), Keith E. Fadgen(2), Kenneth D. Westover(2), Zhejian Ji(2), Nicholas O. Bodnar(2), Tom A. Rapoport(2)