Debbie Willoughby

Biochemistry, Genetics and Molecular Biology · Life Sciences

21h-index2.1kcitations30works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(11), Phosphodiesterase function and regulation(11), Neurobiology and Insect Physiology Research(9), Neuroscience and Neuropharmacology Research(7), Ion Channels and Receptors(6)

Publications30 total

Palmitoylation targets AKAP79 protein to lipid rafts and promotes its regulation of calcium-sensitive adenylyl cyclase type 8.
Journal of Biological Chemistry·2015· 9 citedOpen Access
TRPC1 contributes to the Ca2+-dependent regulation of adenylate cyclases
Biochemical Journal·2014· 18 citedOpen Access
A key phosphorylation site in AC8 mediates regulation of Ca2+-dependent cAMP dynamics by an AC8–AKAP79–PKA signalling complex
Journal of Cell Science·2012· 42 citedOpen Access
Direct Binding Between Orai1 and AC8 Mediates Dynamic Interplay Between Ca <sup>2+</sup> and cAMP Signaling
Science Signaling·2012· 144 cited
Organization of cAMP signalling microdomains for optimal regulation by Ca2+ entry
Biochemical Society Transactions·2012· 27 cited
Palmitoylation Targets AKAP79 Protein to Lipid Rafts and Promotes Its Regulation of Calcium-sensitive Adenylyl Cyclase Type 8
Journal of Biological Chemistry·2011· 92 citedOpen Access
Small Molecule AKAP-Protein Kinase A (PKA) Interaction Disruptors That Activate PKA Interfere with Compartmentalized cAMP Signaling in Cardiac Myocytes
Journal of Biological Chemistry·2010· 104 citedOpen Access
AKAP79/150 Interacts with AC8 and Regulates Ca2+-dependent cAMP Synthesis in Pancreatic and Neuronal Systems
Journal of Biological Chemistry·2010· 81 citedOpen Access
Direct demonstration of discrete Ca2+ microdomains associated with different isoforms of adenylyl cyclase
Journal of Cell Science·2009· 55 citedOpen Access
Capacitative Ca2+ Entry via Orai1 and Stromal Interacting Molecule 1 (STIM1) Regulates Adenylyl Cyclase Type 8
Molecular Pharmacology·2009· 74 citedOpen Access
Live-cell imaging of cAMP dynamics
Nature Methods·2007· 105 cited
Kinetic properties of Ca2+/calmodulin-dependent phosphodiesterase isoforms dictate intracellular cAMP dynamics in response to elevation of cytosolic Ca2+
Cellular Signalling·2007· 29 cited
Dynamic Regulation, Desensitization, and Cross-talk in Discrete Subcellular Microdomains during β2-Adrenoceptor and Prostanoid Receptor cAMP Signaling
Journal of Biological Chemistry·2007· 55 citedOpen Access
Organization and Ca<sup>2+</sup>Regulation of Adenylyl Cyclases in cAMP Microdomains
Physiological Reviews·2007· 443 cited
Dynamic Regulation of cAMP Synthesis through Anchored PKA-Adenylyl Cyclase V/VI Complexes
Molecular Cell·2006· 216 citedOpen Access
Use of single-cell imaging techniques to assess the regulation of cAMP dynamics
Biochemical Society Transactions·2006· 7 cited
An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics
The EMBO Journal·2006· 186 citedOpen Access
Ca2+ stimulation of adenylyl cyclase generates dynamic oscillations in cyclic AMP
Journal of Cell Science·2006· 94 cited
Localized Na+/H+ Exchanger 1 Expression Protects Ca2+-regulated Adenylyl Cyclases from Changes in Intracellular pH
Journal of Biological Chemistry·2005· 45 citedOpen Access
Electrically evoked dendritic pH transients in rat cerebellar Purkinje cells
The Journal of Physiology·2002· 64 citedOpen Access
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Frequent Co-authors

Dermot M.F. Cooper(18), Christof J. Schwiening(8), Antonio Ciruela(6), Nanako Masada(4), Sebastian Wachten(4), R C Thomas(4), Katy L. Everett(3), Michelle L. Halls(3), Enno Klußmann(3), Wei Wong(2), John D. Scott(2), Philipp Skroblin(2), George S. Baillie(2), Miles D. Houslay(2), Ilse Delint‐Ramírez(2), Laura J. Ayling(2), Mario Pagano(2), Mark S. Yeoman(2), Paul R. Benjamin(2), Andrea L. Bauman(1)