Patricio Perez-Villarroel

Moffitt Cancer Center — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index1.2kcitations39works1.82yr avg
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Research Topics

Histone Deacetylase Inhibitors Research(21), Peptidase Inhibition and Analysis(11), Protein Degradation and Inhibitors(11), interferon and immune responses(10), Immunotherapy and Immune Responses(7)

Publications39 total

704 Melanoma cell-intrinsic regulation of tertiary lymphoid structure formation by STING signaling
Regular and Young Investigator Award Abstracts·2025Open Access
Targeting MARCO in combination with anti-CTLA-4 leads to enhanced melanoma regression and immune cell infiltration via macrophage reprogramming
Journal for ImmunoTherapy of Cancer·2025· 6 citedOpen Access
Expression of Concern: A Novel Role for Histone Deacetylase 6 in the Regulation of the Tolerogenic STAT3/IL-10 Pathway in APCs
The Journal of Immunology·2024
Abstract 3918: Targeting MARCO in combination with anti-CTLA4 leads to enhanced melanoma regression and immune cell infiltration via macrophage reprogramming
Cancer Research·2024· 1 cited
1509-B STING signaling-intact tumors display a 12-chemokine gene signature associated with tertiary lymphoid structures and favorable prognosis
2023Open Access
Data from STING Signaling in Melanoma Cells Shapes Antigenicity and Can Promote Antitumor T-cell Activity
2023Open Access
Data from STING Signaling in Melanoma Cells Shapes Antigenicity and Can Promote Antitumor T-cell Activity
2023Open Access
Supplementary Data (for Review only) from STING Signaling in Melanoma Cells Shapes Antigenicity and Can Promote Antitumor T-cell Activity
2023Open Access
Supplementary Data (for Review only) from STING Signaling in Melanoma Cells Shapes Antigenicity and Can Promote Antitumor T-cell Activity
2023Open Access
Epigenetic state determines the in vivo efficacy of STING agonist therapy
Nature Communications·2023· 75 citedOpen Access
912 Epigenetic remodeling enhances therapeutic responses to STING agonism<i> in vivo</i>
Regular and Young Investigator Award Abstracts·2022· 1 citedOpen Access
760 In vivo demethylation-mediated reversal of tumor cell-intrinsic cGAS silencing improves the efficacy of STING agonist therapy
Regular and Young Investigator Award Abstracts·2021· 1 citedOpen Access
179 CD8+CD69+ Expanded Tumor Infiltrating Lymphocytes from Soft Tissue Sarcoma Have Increased Tumor-Specific Functional Capacity
Regular and Young Investigator Award Abstracts·2021· 2 citedOpen Access
Checkpoint blockade accelerates a novel switch from an NKT-driven TNFα response toward a T cell driven IFN-γ response within the tumor microenvironment
Journal for ImmunoTherapy of Cancer·2021· 4 citedOpen Access
Correction: <i>Systemic pro-inflammatory response identifies patients with cancer with adverse outcomes from SARS-CoV-2 infection: the OnCovid Inflammatory Score</i>
Journal for ImmunoTherapy of Cancer·2021· 4 citedOpen Access
Epigenetic reprogramming of tumor cell–intrinsic STING function sculpts antigenicity and T cell recognition of melanoma
Proceedings of the National Academy of Sciences·2021· 155 citedOpen Access
STING Signaling in Melanoma Cells Shapes Antigenicity and Can Promote Antitumor T-cell Activity
Cancer Immunology Research·2019· 87 citedOpen Access
Induction of Tertiary Lymphoid Structures With Antitumor Function by a Lymph Node-Derived Stromal Cell Line
Frontiers in Immunology·2018· 74 citedOpen Access
Essential role for histone deacetylase 11 (HDAC11) in neutrophil biology
Journal of Leukocyte Biology·2017· 61 citedOpen Access
Essential role of HDAC6 in the regulation of PD‐L1 in melanoma
Molecular Oncology·2016· 164 citedOpen Access
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Frequent Co-authors

Eduardo M. Sotomayor(19), Maritza Lienlaf(18), Fengdong Cheng(16), James J. Mulé(15), Tessa Knox(14), Eva Sahakian(14), Rana Falahat(14), Javier Pinilla‐Ibarz(12), Alejandro Villagra(12), Karrune Woan(10), Alejandro Villagra(10), John J. Powers(10), Shari Pilon‐Thomas(10), Glen N. Barber(9), Edward Seto(8), Hongwei Wang(8), Adam W. Mailloux(8), Alan P. Kozikowski(7), Anders Berglund(7), David Woods(7)