James Otto

Medicine · Health Sciences

26h-index4.0kcitations73works0.32yr avg
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Research Topics

Peripheral Artery Disease Management(9), Inflammatory mediators and NSAID effects(8), Angiogenesis and VEGF in Cancer(6), Muscle Physiology and Disorders(6), Mechanical Circulatory Support Devices(6)

Publications73 total

Abstract We0039: Integration of Genome-Wide Association Studies with Single Cell Chromatin Accessibility Data Identifies a Fibro-Adipogenic Progenitor (FAP) Enhancer and Mmp1 and Mmp3 as Novel Targets for PAD
JVS Vascular Science·2026Open Access
Abstract We0085: Senescent Cells Accumulate in the Ischemic Limb
Arteriosclerosis Thrombosis and Vascular Biology·2025
Abstract We0086: Transcriptomic Profiling Links Senescent Fibro-Adipogenic Progenitors to Amputation and Mortality in Human Chronic Limb Threatening Ischemia Patients
Arteriosclerosis Thrombosis and Vascular Biology·2025
Abstract We0039: Integration of Genome-Wide Association Studies with Single Cell Chromatin Accessibility Data Identifies a Fibro-Adipogenic Progenitor (FAP) Enhancer and Mmp1 and Mmp3 as Novel Targets for PAD.
Arteriosclerosis Thrombosis and Vascular Biology·2025
Vascular adhesion molecule 1+ fibro-adipogenic progenitors mark fatty infiltration in chronic limb-threatening ischemia
JVS Vascular Science·2025Open Access
Vcam1+ Fibro-adipogenic Progenitors Mark Fatty Infiltration in Chronic Limb Threatening Ischemia
2024· 1 citedOpen Access
Abstract 142: Nr3c1-Sfrp1 Axis Regulates The Adipogenic Differentiation Of Vcam1+ Fibro-adipogenic Progenitors In Chronic Limb Threatening Ischemia
Arteriosclerosis Thrombosis and Vascular Biology·2024
Nr3c1-Sfrp1 Axis Regulates the Adipogenic Differentiation of Vcam1+ Fibro-adipogenic Progenitors in Chronic Limb-threatening Ischemia
JVS Vascular Science·2024Open Access
Skeletal muscle regeneration failure in ischemic-damaged limbs is associated with pro-inflammatory macrophages and premature differentiation of satellite cells
Genome Medicine·2023· 34 citedOpen Access
Abstract 18426: Secreted Frizzled-Related Protein 1 Mediates Adipogenic Differentiation of Vascular Cell Adhesion Protein 1 Fibroadipogenic Progenitors in the Ischemic Limb
Circulation·2023
Subgrouping of facilitatory or inhibitory conditioned pain modulation responses in patients with chronic knee pain. Explorative analysis from a multicentre trial
European Journal of Pain·2023· 8 citedOpen Access
Individual conditioned pain modulation responses in patients with chronic pain:Explorative findings from a multicenter trial
VBN Forskningsportal (Aalborg Universitet)·2023
Abstract 604: Distinct Fibroadipogenic Progenitor Populations And Trajectories Characterize Regenerative And Non-regenerative Responses In The Ischemic Limb
Arteriosclerosis Thrombosis and Vascular Biology·2023
Abstract 535: Vascular Cell Adhesion Molecule 1 Positive Fibroadipogenic Progentiors Promote Adipogenesis In Chronic Limb Threatening Ischemia Patients
Arteriosclerosis Thrombosis and Vascular Biology·2023
Abstract 134: A Single-cell Atlas Of Human Skeletal Muscle Tissue In Chronic Limb-threatening Ischemia
Arteriosclerosis Thrombosis and Vascular Biology·2023
Pro-inflammatory macrophages impair skeletal muscle regeneration in ischemic-damaged limbs by inducing precocious differentiation of satellite cells
2023· 2 citedOpen Access
Vascular Cell Adhesion Molecule 1-Positive Fibroadipogenic Progentiors Promote Adipogenesis in Chronic-Limb Threatening Ischemia Patients
JVS Vascular Science·2023Open Access
A Single-cell Atlas of Human Skeletal Muscle Tissue in Chronic Limb-threatening Ischemia
JVS Vascular Science·2023Open Access
Aptamer-based factor IXa inhibition preserves hemostasis and prevents thrombosis in a piglet model of ECMO
Molecular Therapy — Nucleic Acids·2021· 14 citedOpen Access
Coagulopathy Characterized by Rotational Thromboelastometry in a Porcine Pediatric ECMO Model
Journal of ExtraCorporeal Technology·2020· 3 citedOpen Access
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Frequent Co-authors

Patrick J. Casey(9), William L. Smith(8), John D. York(7), Stephen G. Young(7), Elisabeth T. Tracy(6), Amy F. Barabasz(5), Briana Foley(5), Patricia Ambroziak(5), Martin O. Bergö(5), David L. DeWitt(4), Peter C. Fridy(4), James M. Veal(4), John W. Rice(4), Gunnar J. Hanson(4), Steven E. Hall(4), Kevin W. Southerland(4), Yueyuan Xu(4), Kaileen Fei(4), Lindsey A. Olivere(4), Qunsheng Dai(4)