James A. Dykens

Biochemistry, Genetics and Molecular Biology · Life Sciences

31h-index5.7kcitations76works0.02yr avg
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Research Topics

Mitochondrial Function and Pathology(21), Metabolism and Genetic Disorders(16), Estrogen and related hormone effects(13), Menopause: Health Impacts and Treatments(12), Metabolomics and Mass Spectrometry Studies(6)

Publications76 total

Index
2018
Front Matter
2018
Front Matter
2018
Supplemental Images
2018
Supplemental Images
2018Open Access
Introduction to basic mitochondrial biology as it relates to drug-induced toxicity
Drug Metabolism and Pharmacokinetics·2018
Mitochondrial Drugs Come of Age
Drug Development Research·2015· 9 cited
Mitochondrial toxicity assessment in industry – a decade of technology development and insight
Expert Opinion on Drug Metabolism & Toxicology·2014· 139 cited
Mitochondrial Toxicity
Elsevier eBooks·2014· 5 cited
Optimising cell models for detecting drug-induced mitochondrial dysfunction
Toxicology·2010· 1 cited
Development and validation of a pre-clinically relevant phototoxicity screen
Toxicology·2010
Biomarkers of in Vitro Drug‐Induced Mitochondrial Dysfunction
Biomarkers·2010
CD34+ cell expansion model for the in vitro assessment of haematotoxicity
Toxicology Letters·2010
Mitochondrial mechanisms of estrogen neuroprotection
Biochimica et Biophysica Acta (BBA) - General Subjects·2009· 193 citedOpen Access
Introduction to Mitochondrial Toxicity
General, Applied and Systems Toxicology·2009
Predicting Drug‐Induced Hepatotoxicity:<i>In Vitro</i>,<i>In Silico</i>and<i>In Vivo</i>Approaches
Methods and principles in medicinal chemistry·2009· 3 cited
A current practice for predicting ocular toxicity of systemically delivered drugs
Cutaneous and Ocular Toxicology·2009· 27 cited
Review of the effects of 17α‐estradiol in humans: a less feminizing estrogen with neuroprotective potential
Drug Development Research·2009· 29 citedOpen Access
Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro
Toxicology and Applied Pharmacology·2008· 220 cited
Effect of the Multitargeted Tyrosine Kinase Inhibitors Imatinib, Dasatinib, Sunitinib, and Sorafenib on Mitochondrial Function in Isolated Rat Heart Mitochondria and H9c2 Cells
Toxicological Sciences·2008· 213 cited
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Frequent Co-authors

Yvonne Will(10), James W. Simpkins(6), J. Malcolm Shick(6), Walter H. Moos(6), Lisa D. Marroquin(5), Sashi Nadanaciva(4), Neil Howell(4), Arnold Stern(3), Joseph Jamieson(3), C. P. Mangum(3), James T. Hynes(2), Ran Liu(2), László Prókai(2), Kristen Johnson(2), Alexander Y. Andreyev(2), Robert Terkeltaub(2), Shao‐Hua Yang(2), Xiaofei Wang(2), Evelyn Perez(2), Douglas F. Covey(2)