Douglas F. Covey

Washington University in St. Louis — United States

Neuroscience · Life Sciences

72h-index16.8kcitations453works19.12yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(143), Ion channel regulation and function(64), Receptor Mechanisms and Signaling(63), Estrogen and related hormone effects(52), Cholesterol and Lipid Metabolism(38)

Publications452 total

Target validation uncouples TSPO from 19-Atriol-mediated inhibition of steroidogenesis and reveals true enzymatic targets
2025Open Access
Live-cell imaging and lipidomics of low density lipoprotein containing intrinsically fluorescent cholesteryl esters
2025Open Access
Unravelling the multifaceted actions of neurosteroids: Machine learning and in vitro screening for novel target discovery
British Journal of Pharmacology·2025· 1 cited
Phosphorylation of CRYAB induces a condensatopathy to worsen post–myocardial infarction left ventricular remodeling
Journal of Clinical Investigation·2025· 2 citedOpen Access
Facilitation of Ca <sub>V</sub> 3.2 channel gating in pain pathways reveals a novel mechanism of serum-induced hyperalgesia
2025· 1 citedOpen Access
Endogenous and fluorescent sterols reveal the molecular basis for ligand selectivity of human sterol transporters
Journal of Lipid Research·2024· 6 citedOpen Access
Stereospecific Properties and Intracellular Transport of Novel Intrinsically Fluorescent Neurosteroids
ACS Chemical Neuroscience·2024· 2 citedOpen Access
Phosphorylation of CRYAB Induces a Condensatopathy to Worsen Post-Myocardial Infarction Left Ventricular Remodeling
2024· 1 citedOpen Access
Inhibitory Actions of Potentiating Neuroactive Steroids in the Human α1β3γ2L γ-Aminobutyric Acid Type A Receptor
Molecular Pharmacology·2024· 3 citedOpen Access
Endogenous and fluorescent sterols reveal the molecular basis for ligand selectivity of human sterol transporters
2024· 1 citedOpen Access
Direct measurements of neurosteroid binding to specific sites on GABA<sub>A</sub> receptors
British Journal of Pharmacology·2024· 5 citedOpen Access
Neurosteroids mediate and modulate the effects of pro-inflammatory stimulation and toll-like receptors on hippocampal plasticity and learning
PLoS ONE·2024· 10 citedOpen Access
Comparison of Behavioral Effects of GABAergic Low- and High-Efficacy Neuroactive Steroids in the Zebrafish Larvae Assay
ACS Chemical Neuroscience·2024· 1 citedOpen Access
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway
Nature Structural & Molecular Biology·2024· 33 citedOpen Access
7-Dehydrocholesterol is an endogenous suppressor of ferroptosis
Nature·2024· 254 cited
Neuroactive steroid effects on autophagy in a human embryonic kidney 293 (HEK) cell model
Scientific Reports·2024· 1 citedOpen Access
Synthesis and evaluation of photoaffinity labeling reagents for identifying binding sites of sulfated neurosteroids on NMDA and GABA<sub>A</sub> receptors
RSC Advances·2024· 4 citedOpen Access
Ergosterol mediates aggregation of natamycin in the yeast plasma membrane
2023· 1 citedOpen Access
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway
2023· 7 citedOpen Access
Neurosteroid enantiomers as potentially novel neurotherapeutics
Neuroscience & Biobehavioral Reviews·2023· 27 citedOpen Access
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Frequent Co-authors

Charles F. Zorumski(10), Steven Mennerick(9), Kathiresan Krishnan(6), Rajat Rohatgi(5), Alex S. Evers(5), Sigrid Nachtergaele(4), Christian Siebold(4), Joe Henry Steinbach(4), Gustav Akk(4), Laurel Mydock‐McGrane(3), Daniel S. Ory(3), Giovanni Luchetti(3), Steven M. Paul(3), Emily J. Westover(3), Lawrence N. Eisenman(3), Miljen M. Jagodic(3), Slobodan M. Todorovic(3), Mingxing Qian(3), Xuntian Jiang(2), Oliver B. Davis(2)