Giovanni Luchetti

Biochemistry, Genetics and Molecular Biology · Life Sciences

13h-index1.4kcitations30works0.02yr avg
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Research Topics

Hedgehog Signaling Pathway Studies(13), Epigenetics and DNA Methylation(7), Genomics and Chromatin Dynamics(5), Genetic and Kidney Cyst Diseases(3), Asymmetric Synthesis and Catalysis(2)

Publications30 total

Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion
Nature·2025Open Access
Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain
Science Advances·2022· 57 citedOpen Access
Simulations for: Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain.
Zenodo (CERN European Organization for Nuclear Research)·2022Open Access
Simulations for: Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain.
2022Open Access
Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes
eLife·2021· 60 citedOpen Access
Author response: Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes
2021Open Access
Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection
Cell Host & Microbe·2021· 175 citedOpen Access
Cholesterol as a Second Messenger in the Hedgehog Signaling Pathway
The FASEB Journal·2021
Cholesterol accessibility at the ciliary membrane controls hedgehog signaling
eLife·2019· 148 citedOpen Access
Author response: Cholesterol accessibility at the ciliary membrane controls hedgehog signaling
2019· 6 citedOpen Access
Sphingomyelin suppresses Hedgehog signaling by restricting cholesterol accessibility at the ciliary membrane
2019Open Access
G protein–coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog
Science Signaling·2018· 100 citedOpen Access
Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates
Current Opinion in Cell Biology·2017· 57 cited
Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling
eLife·2016· 240 citedOpen Access
Author response: Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling
2016Open Access
Cholesterol activates the G-protein coupled receptor Smoothened to promote morphogenetic signaling
2016· 2 citedOpen Access
Structural basis of Smoothened regulation by its extracellular domains
Nature·2016· 358 citedOpen Access
Structure of human Smoothened in complex with Vismodegib
2016
Tracking the Subcellular Fate of 20(S)-Hydroxycholesterol with Click Chemistry Reveals a Transport Pathway to the Golgi
Journal of Biological Chemistry·2014· 24 citedOpen Access
Ric1-Rgp1 Complex Is a Guanine Nucleotide Exchange Factor for the Late Golgi Rab6A GTPase and an Effector of the Medial Golgi Rab33B GTPase
Journal of Biological Chemistry·2012· 71 citedOpen Access
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Frequent Co-authors

Rajat Rohatgi(17), Christian Siebold(15), Douglas F. Covey(13), Ria Sircar(11), Sigrid Nachtergaele(9), Maia Kinnebrew(9), Jennifer H. Kong(8), Eamon F.X. Byrne(6), Laurel Mydock‐McGrane(6), Ganesh V. Pusapati(6), Arun Radhakrishnan(6), Mark S.P. Sansom(5), Simon Newstead(5), Bhaven B. Patel(5), Igor V. Magedov(5), Alexander Kornienko(5), Sara Frigui(5), Andreas Sagner(4), Ellen J. Iverson(4), Nikolai M. Evdokimov(4)