Sigrid Nachtergaele

University of California, Irvine — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

24h-index10.2kcitations43works0.42yr avg
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Research Topics

RNA modifications and cancer(21), Hedgehog Signaling Pathway Studies(12), RNA Research and Splicing(11), Epigenetics and DNA Methylation(9), Cancer-related molecular mechanisms research(8)

Publications43 total

Investigation of TRMT61B methyltransferase activity on mRNA and its effects on translation
2025Open Access
<i>N</i> <sup>6</sup> -methyladenosine promotes temozolomide resistance through mRNA stabilization in glioblastoma cells
2025Open Access
Abstract 2746 mRNA stabilization by chemical modifications in drug-resistant glioblastoma
Journal of Biological Chemistry·2025Open Access
Combating the myth of “innate genius” in science
Cell chemical biology·2024
A user guide to RT-based mapping of RNA modifications
Methods in enzymology on CD-ROM/Methods in enzymology·2024· 2 cited
mRNA Regulation by RNA Modifications
Annual Review of Biochemistry·2023· 115 citedOpen Access
Enzymes flying under the radar: Cryptic METTL3 can persist in knockout cells
PLoS Biology·2022Open Access
Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain
Science Advances·2022· 57 citedOpen Access
Transcriptome-wide mapping reveals a diverse dihydrouridine landscape including mRNA
PLoS Biology·2022· 47 citedOpen Access
Simulations for: Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain.
Zenodo (CERN European Organization for Nuclear Research)·2022Open Access
Simulations for: Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain.
2022Open Access
New Vistas for Cell-Surface GlycoRNAs
New England Journal of Medicine·2021· 20 cited
The METTL5-TRMT112 <i> N <sup>6</sup> </i> -methyladenosine methyltransferase complex regulates metabolism and development via translation
2021Open Access
Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation
Nature Communications·2020· 78 citedOpen Access
Publisher Correction: Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
Nature Cell Biology·2020· 48 citedOpen Access
Evolution of a reverse transcriptase to map N1-methyladenosine in human messenger RNA
Nature Methods·2019· 203 cited
Chemical Modifications in the Life of an mRNA Transcript
Annual Review of Genetics·2018· 235 citedOpen Access
Author Correction: Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
Nature Cell Biology·2018· 61 citedOpen Access
Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
Nature Cell Biology·2018· 3.0k citedOpen Access
R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling
Cell·2017· 1.2k citedOpen Access
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Frequent Co-authors

Rajat Rohatgi(17), Douglas F. Covey(15), Chuan He(12), Christian Siebold(12), Giovanni Luchetti(9), Ria Sircar(8), Kathiresan Krishnan(7), Laurel Mydock‐McGrane(6), Laurel K. Mydock(6), Huilin Huang(5), Hengyou Weng(5), Xi Qin(5), Rui Su(5), Lei Dong(5), Yungui Wang(5), Xi Jiang(5), Jianjun Chen(5), Eamon F.X. Byrne(5), Mark S.P. Sansom(5), Simon Newstead(5)