Jun Zhu

University of South Carolina — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

30h-index3.1kcitations114works1.72yr avg
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Research Topics

Receptor Mechanisms and Signaling(30), HIV Research and Treatment(28), HIV/AIDS drug development and treatment(22), Nicotinic Acetylcholine Receptors Study(21), Neurotransmitter Receptor Influence on Behavior(20)

Publications114 total

HIV-1 Tat Protein Exposure Alters the Morphological Characteristics and Gene Expression in the Primary Mouse Cortex Endothelial Cells and Human Brain Microvascular Endothelial Cells
Cellular and Molecular Neurobiology·2025Open Access
Mutational effects of the asparagine198 and glutamate223 residues on the human norepinephrine transporter on basal and HIV-1 Tat protein-induced inhibition of dopamine transport
European Journal of Pharmacology·2025· 2 citedOpen Access
Synthesis and evaluation of novel substituted N-(2-phenylbutyl)-5,6,7,8-tetrahydro-quinazolin-4-amines as allosteric modulators of HIV-DAT-tat interaction
Bioorganic & Medicinal Chemistry Letters·2025
Synthesis and Evaluation of Novel Substituted N-(2-phenylbutyl)-5,6,7,8-tetrahydro-quinazolin-4-amines as Allosteric Modulators of HIV-DAT-Tat Interaction
SSRN Electronic Journal·2025Open Access
Impact of HIV-1 tat protein on methamphetamine-induced inhibition of vesicular monoamine transporter2-mediated dopamine transport and methamphetamine conditioned place preference in HIV-1 tat transgenic mice
European Journal of Pharmacology·2024· 4 citedOpen Access
Identification of pyrimidine structure-based compounds as allosteric ligands of the dopamine transporter as therapeutic agents for NeuroHIV
Journal of Pharmacology and Experimental Therapeutics·2024· 1 cited
Effects of SRI-32743, a Novel Quinazoline Structure-Based Compound, on HIV-1 Tat and Cocaine Interaction with Norepinephrine Transporter
International Journal of Molecular Sciences·2024· 5 citedOpen Access
Potential association of genetically predicted lipid and lipid-modifying drugs with rheumatoid arthritis: A Mendelian randomization study
PLoS ONE·2024· 3 citedOpen Access
Molecular mechanisms of dopaminergic transmission in NeuroHIV
Elsevier eBooks·2024
SRI-30827, a novel allosteric modulator of the dopamine transporter, alleviates HIV-1 Tat-induced potentiation of cocaine conditioned place preference in mice
NeuroImmune Pharmacology and Therapeutics·2023Open Access
The Impact of Neurotransmitters on the Neurobiology of Neurodegenerative Diseases
International Journal of Molecular Sciences·2023· 41 citedOpen Access
Novel Allosteric Modulator Southern Research Institute-32743 Reverses HIV-1 Transactivator of Transcription-Induced Increase in Dopamine Release in the Caudate Putamen of Inducible Transactivator of Transcription Transgenic Mice
Journal of Pharmacology and Experimental Therapeutics·2022· 8 citedOpen Access
Mutations of tyrosine 467 in the human norepinephrine transporter attenuate HIV-1 Tat-induced inhibition of dopamine transport while retaining physiological function
PLoS ONE·2022· 5 citedOpen Access
SRI-32743, a novel allosteric modulator, attenuates HIV-1 Tat protein-induced inhibition of the dopamine transporter and alleviates the potentiation of cocaine reward in HIV-1 Tat transgenic mice
Neuropharmacology·2022· 21 cited
Substance abuse and neurotransmission
Advances in pharmacology·2022· 9 citedOpen Access
Binding Mode of Human Norepinephrine Transporter Interacting with HIV-1 Tat
ACS Chemical Neuroscience·2021· 6 citedOpen Access
Mutations of Human DopamineTransporter at Tyrosine88, Aspartic Acid206, and Histidine547 Influence Basal and HIV-1 Tat‐inhibited Dopamine Transport
Journal of Neuroimmune Pharmacology·2021· 11 citedOpen Access
Yolk sac-derived Pdcd11-positive cells modulate zebrafish microglia differentiation through the NF-κB-Tgfβ1 pathway
Cell Death and Differentiation·2020· 17 citedOpen Access
[3H]Dopamine Uptake through the Dopamine and Norepinephrine Transporters is Decreased in the Prefrontal Cortex of Transgenic Mice Expressing HIV-1 Transactivator of Transcription Protein
Journal of Pharmacology and Experimental Therapeutics·2020· 24 citedOpen Access
VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease
Science·2019· 681 citedOpen Access
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Frequent Co-authors

Linda P. Dwoskin(11), Chang‐Guo Zhan(10), Narasimha M. Midde(10), Wei‐Lun Sun(8), Pamela M. Quizon(8), Yaxia Yuan(7), Adrian M. Gomez(7), Michael T. Bardo(6), Rosemarie M. Booze(5), Charles F. Mactutus(4), Xiaoqin Huang(4), Subramaniam Ananthan(4), Matthew J. Strauss(3), Agripina G. Deaciuc(3), Peter A. Crooks(3), Fumiko Suzuki(3), Takanobu Taniguchi(3), Steven B. Harrod(3), Ikunobu Muramatsu(3), Subbu Apparsundaram(2)