Yaxia Yuan

The University of Texas Health Science Center at San Antonio — United States

Computer Science · Physical Sciences

25h-index3.3kcitations98works4.82yr avg
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Research Topics

Computational Drug Discovery Methods(20), Protein Degradation and Inhibitors(19), Ubiquitin and proteasome pathways(16), HIV Research and Treatment(11), HIV/AIDS drug development and treatment(11)

Publications95 total

Design, synthesis, and activity evaluation of RET protein degradation based on PROTAC and HyTTD techniques
Bioorganic & Medicinal Chemistry Letters·2026
Rational design of an NLRP3 inhibitor with superior efficacy and safety for gout therapy
European Journal of Medicinal Chemistry·2026
Polysaccharides of Atractylodes Macrocephala Koidz effectively improve the EpCAM+/− genotype-related inflammatory bowel diseases via modulating gut microbiota
International Journal of Biological Macromolecules·2025
SAT-298 Structural and Functional Analysis of Pheochromocytoma Tumor Suppressor TMEM127 Reveals its Mechanism of Interaction with E3 Ubiquitin Ligases and Substrate MHC-I
Journal of the Endocrine Society·2025Open Access
Discovery of Dual BCL-xL/BCL-w Degraders by Exploiting the Bis(sulfonyl)benzene Ring of ABT-263 as a Linkage Vector
Journal of Medicinal Chemistry·2025· 1 cited
Ewing sarcoma depends on C4orf48/NICOL, a NELL2 cofactor regulated by Hippo signaling
Cellular Signalling·2025
Hit to lead optimization of isopentenyl chalcones as novel MTHFD2 inhibitors for cancer treatment: design, synthesis, in-vitro, in-vivo and in-silico studies
European Journal of Medicinal Chemistry·2025· 2 cited
Abstract 7201: Targeting SLC38A1 non-conventional glutamine transporter in high risk MDS/AML
Cancer Research·2025· 1 cited
Computational Design and In Vitro and In Vivo Characterization of an ApoE-Based Synthetic High-Density Lipoprotein for Sepsis Therapy
Biomolecules·2025Open Access
PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1
Cell stem cell·2025· 10 citedOpen Access
Design and synthesis of JNK1-targeted PROTACs and research on the activity
Bioorganic Chemistry·2024· 2 cited
Discovery of a selective and potent inhibitor of c-Jun N-terminal kinase 1 with anti-pulmonary fibrosis effect
Bioorganic & Medicinal Chemistry Letters·2024· 2 cited
Protein Degrader WH25244 Eliminates Venetoclax Resistance Factors: Mutant or Hyperphosphorylated BCL2, and BCL-XL
Blood·2024· 1 cited
Design, synthesis and biological evaluation of sulfonylurea derivatives as NLRP3 inflammasome inhibitors
Bioorganic & Medicinal Chemistry Letters·2024· 4 cited
Structure Optimization of c-Jun N-terminal Kinase 1 Inhibitors for Treating Idiopathic Pulmonary Fibrosis
Journal of Medicinal Chemistry·2024· 5 cited
Targeted Protein Degradation: Current and Emerging Approaches for E3 Ligase Deconvolution
Journal of Medicinal Chemistry·2024· 25 citedOpen Access
Abstract PO3-26-10: Small molecule inhibitor of PELP1 exhibit cytotoxic effects on breast cancer cells by blocking ribosome biogenesis
Cancer Research·2024
Total synthesis/semi-synthesis of natural isopentenyl flavonoids with inhibitory activity on NLRP3 inflammasome
Bioorganic & Medicinal Chemistry Letters·2024· 7 citedOpen Access
Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL
Nature Communications·2024· 36 citedOpen Access
TATDN2 resolution of R-loops is required for survival of BRCA1-mutant cancer cells
Nucleic Acids Research·2023· 14 citedOpen Access
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Frequent Co-authors

Chang‐Guo Zhan(22), Daohong Zhou(18), Guangrong Zheng(14), Xuan Zhang(11), Dongwen Lv(9), Xingui Liu(9), Jun Zhu(9), Shuo Zhou(8), Wei‐Lun Sun(8), Pamela M. Quizon(8), Sajid Khan(7), Peiyi Zhang(7), Jianfeng Pei(7), Luhua Lai(7), Dinesh Thummuri(6), Robert Hromas(6), Yonghan He(5), Wanyi Hu(5), Kai Ding(5), Fang Zheng(5)