Dongwen Lv

The University of Texas Health Science Center at San Antonio — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

34h-index3.7kcitations67works11.82yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Protein Degradation and Inhibitors(22), Ubiquitin and proteasome pathways(17), Peptidase Inhibition and Analysis(15), Wheat and Barley Genetics and Pathology(9), Multiple Myeloma Research and Treatments(8)

Publications67 total

An unbiased proteomic platform for ATE1-based arginylation profiling
Nature Chemical Biology·2025· 4 citedOpen Access
CD36-mediated endocytosis of proteolysis-targeting chimeras
Cell·2025· 30 cited
Discovery of PZ671, a highly potent and <i>in vivo</i> active CRBN-recruiting Bcl-xL degrader
RSC Medicinal Chemistry·2025· 1 citedOpen Access
Development of first-in-class PROTAC degraders of TAK1
2024Open Access
An Unbiased Proteomic Platform for ATE1-based Arginylation Profiling
2024· 3 citedOpen Access
NSD2 drives t(4;14) myeloma cell dependence on adenylate kinase 2 by diverting one-carbon metabolism to the epigenome
Blood·2024· 12 citedOpen Access
Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL
Nature Communications·2024· 36 citedOpen Access
Abstract 7058: NSD2 overexpression drives multiple myeloma dependence on adenylate kinase 2 by diverting one-carbon metabolism to the epigenome
Cancer Research·2024
PROTAC-mediated NR4A1 degradation as a novel strategy for cancer immunotherapy
The Journal of Experimental Medicine·2024· 20 citedOpen Access
Bifunctional Peptide Nanofibrils for Targeted Protein Degradation
Angewandte Chemie International Edition·2023· 10 citedOpen Access
Bifunctional Peptide Nanofibrils for Targeted Protein Degradation
Angewandte Chemie·2023
Automation to Enable High-Throughput Chemical Proteomics
Journal of Proteome Research·2023· 6 citedOpen Access
HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation
Cell chemical biology·2023· 36 citedOpen Access
Abstract 4792: Characterizing cellular senescence response to senolytic compounds using cell culture media analysis
Cancer Research·2023
Piperlongumine conjugates induce targeted protein degradation
Cell chemical biology·2023· 65 citedOpen Access
Piperlongumine (PL) conjugates induce targeted protein degradation
2022· 6 citedOpen Access
Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity,
Nature Communications·2021· 140 citedOpen Access
Discovery of a Novel BCL-X<sub>L</sub> PROTAC Degrader with Enhanced BCL-2 Inhibition
Journal of Medicinal Chemistry·2021· 54 citedOpen Access
Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies
Journal of Hematology & Oncology·2020· 113 citedOpen Access
DT2216—a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas
Journal of Hematology & Oncology·2020· 118 citedOpen Access
page 1 of 4Next →

Frequent Co-authors

Daohong Zhou(17), Guangrong Zheng(15), Xuan Zhang(13), Xiaohui Li(12), Yaxia Yuan(10), Xingui Liu(9), Yueming Yan(9), Guanxing Chen(8), Yonghan He(7), Peiyi Zhang(7), Yueming Yan(7), Yueming Yan(7), Sajid Khan(6), Dinesh Thummuri(6), Pei Ge(6), Yanwei Bian(6), Kun Zhang(6), Renfeng Li(6), Jing Pei(5), Robert Hromas(5)