Dominika Chalupská

Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry — Czech Republic

Biochemistry, Genetics and Molecular Biology · Life Sciences

21h-index1.7kcitations54works3.82yr avg
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Research Topics

RNA and protein synthesis mechanisms(10), Cellular transport and secretion(8), interferon and immune responses(6), Pancreatic function and diabetes(5), Bacteriophages and microbial interactions(5)

Publications54 total

Structural mechanism and inhibitor discovery for DhhP, a Borrelia burgdorferi cyclic di-AMP phosphodiesterase with an Fe/Mn bimetallic center
Structure·2026Open Access
Exploring advanced methodologies for NS5 methyltransferase targeted drug discovery
European Journal of Medicinal Chemistry·2025Open Access
Exploring Advanced Methodologies for NS5 Methyltransferase Targeted Drug Discovery
SSRN Electronic Journal·2025Open Access
Structural and functional insights in flavivirus NS5 proteins gained by the structure of Ntaya virus polymerase and methyltransferase
Structure·2024· 6 citedOpen Access
Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function
Structure·2024· 6 citedOpen Access
Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5′-carboxamides
RSC Medicinal Chemistry·2024· 11 citedOpen Access
Design, synthesis and evaluation of novel thieno[2,3d]pyrimidine derivatives as potent and specific RIPK2 inhibitors
Bioorganic & Medicinal Chemistry Letters·2023· 1 citedOpen Access
Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: structural basis of their function
2023· 2 citedOpen Access
Exploring positions 6 and 7 of a quinazoline-based scaffold leads to changes in selectivity and potency towards RIPK2/3 kinases
European Journal of Medicinal Chemistry·2023· 5 citedOpen Access
Rational Design of Highly Potent SARS-CoV-2 nsp14 Methyltransferase Inhibitors
ACS Omega·2023· 28 citedOpen Access
Structural basis for RNA-cap recognition and methylation by the mpox methyltransferase VP39
Antiviral Research·2023· 16 citedOpen Access
Subunit-Dependent Surface Mobility and Localization of NMDA Receptors in Hippocampal Neurons Measured Using Nanobody Probes
Journal of Neuroscience·2023· 6 citedOpen Access
Structural and functional insights in flavivirus NS5 proteins gained by the structure of Ntaya virus polymerase and methyltransferase
2023Open Access
Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase
Nature Communications·2023· 50 citedOpen Access
Rational design of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors
2023Open Access
Structural and Functional Insights in Flavivirus NS5 Proteins Gained by the Structure of Ntaya Virus Polymerase and Methyltransferase
SSRN Electronic Journal·2023· 1 citedOpen Access
Design, Synthesis and Evaluation of Novel Thieno[2,3,<i>d</i>]Pyrimidine Derivatives as Potent and Specific RIPK2 Inhibitors
SSRN Electronic Journal·2023Open Access
Synthesis of Novel 3’,3’‐cyclic Dinucleotide Analogues Targeting STING Protein
Asian Journal of Organic Chemistry·2022· 5 citedOpen Access
The pathogenic N650K variant in the GluN1 subunit regulates the trafficking, conductance, and pharmacological properties of NMDA receptors
Neuropharmacology·2022· 16 citedOpen Access
The structure of monkeypox virus 2′-O-ribose methyltransferase VP39 in complex with sinefungin provides the foundation for inhibitor design
Research Square (Research Square)·2022Open Access
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Frequent Co-authors

Evžen Bouřa(40), Martin Klíma(25), Radim Nencka(21), Michal Šála(12), Milan Dejmek(12), Karel Chalupský(12), Adriana Bäumlová(10), Jan Šilhán(9), Helena Mertlíková‐Kaiserová(9), Petra Krafčíková(9), Jana Humpolíčková(8), Jan Weber(6), Bartosz Różycki(6), Václav Veverka(5), Ivana Mejdrová(5), Marika Matoušová(5), Tomáš Otava(5), Jan Kozic(5), Tamás Balla(4), Piotr Górnicki(4)