Kevin M. Guckian

Biogen (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index2.7kcitations42works0.02yr avg
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Research Topics

DNA and Nucleic Acid Chemistry(12), Advanced biosensing and bioanalysis techniques(6), DNA Repair Mechanisms(4), Cell Adhesion Molecules Research(4), Sphingolipid Metabolism and Signaling(4)

Publications42 total

Determination of steady state brain KP,UU of BIDAC(TM) degraders using chemical knock out animal models
Drug Metabolism and Pharmacokinetics·2025
ILC2s navigate tissue redistribution during infection using stage-specific S1P receptors
2024Open Access
Development of a PET Tracer for OGA with Improved Kinetics in the Living Brain
Journal of Nuclear Medicine·2023· 11 citedOpen Access
Development of a Novel [<sup>11</sup>C]CO-Labeled Positron Emission Tomography Radioligand [<sup>11</sup>C]BIO-1819578 for the Detection of <i>O</i>-GlcNAcase Enzyme Activity
ACS Chemical Neuroscience·2023· 7 citedOpen Access
Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides
Nucleic Acids Research·2023· 18 citedOpen Access
Selective TYK2 inhibitors as potential therapeutic agents: a patent review (2019–2021)
Expert Opinion on Therapeutic Patents·2022· 23 cited
Glycoside Hydrolases as Therapeutic Targets for CNS Indications
2021· 1 cited
Linked PDF of Table of Contents
Synlett·2021Open Access
A Simple, Readily Accessible, and Effective Apparatus for the Photoisomerization of cis-Cyclooctenes to trans-Cyclooctenes
Synlett·2021· 3 cited
Chemoproteomic Profiling of Covalent XPO1 Inhibitors to Assess Target Engagement and Selectivity
ChemBioChem·2021· 8 cited
Novel Potent Selective Orally Active S1P5 Receptor Antagonists
ACS Medicinal Chemistry Letters·2021· 7 citedOpen Access
FRI0216B SELECTIVE IRAK4 INHIBITOR DAMPENS MYD88 SIGNALING AND AMELIORATES INFLAMMATION AND FIBROSIS IN A MOUSE MODEL OF LUPUS NEPHRITIS
Annals of the Rheumatic Diseases·2019Open Access
Iconography : S1PR5 is essential for human natural killer cell migration toward sphingosine-1 phosphate
2018
Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction
Scientific Reports·2018· 26 citedOpen Access
Lock and chop: A novel method for the generation of a PICK1 PDZ domain and piperidine‐based inhibitor co‐crystal structure
Protein Science·2017· 22 citedOpen Access
S1PR5 is essential for human natural killer cell migration toward sphingosine-1 phosphate
Journal of Allergy and Clinical Immunology·2017· 51 cited
Small Molecule Inhibition of Interleukin-1 Receptor-Associated Kinase 4 (IRAK4)
Progress in medicinal chemistry·2017· 22 cited
Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury
Journal of Clinical Investigation·2016· 145 citedOpen Access
Synapto‐depressive effects of amyloid beta require <scp>PICK</scp>1
European Journal of Neuroscience·2014· 64 citedOpen Access
Inhibition of LFA‐1/ICAM Interaction for the Treatment of Autoimmune Diseases
Methods and principles in medicinal chemistry·2013· 2 cited
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Frequent Co-authors

Eric T. Kool(12), Edward Yin-Shiang Lin(9), Laura Silvian(5), Robert H. Scannevin(5), Nathan E. Genung(5), Juan Carlos Morales(4), G. Kumaravel(4), Alan Saghatelian(3), M. Reza Ghadiri(3), Charles C. Banos(3), Anthone W. Dunah(3), Annabelle Drouillard(3), Michaël Mingueneau(3), Thierry Walzer(3), Wen‐Cherng Lee(3), Daniel M. Scott(3), Heike Hering(3), Chunhua Yang(3), Barbara A. Schweitzer(2), Rex X. Ren(2)