Luca Giovanni Di Giovannantonio

Institute of Genetics and Biophysics — Italy

Neuroscience · Life Sciences

17h-index1.3kcitations21works0.02yr avg
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Research Topics

Nuclear Receptors and Signaling(9), Pluripotent Stem Cells Research(7), Genetics and Neurodevelopmental Disorders(6), Neurogenesis and neuroplasticity mechanisms(4), Parkinson's Disease Mechanisms and Treatments(3)

Publications21 total

Common and Rare Variants in TMEM175 Gene Concur to the Pathogenesis of Parkinson’s Disease in Italian Patients
Molecular Neurobiology·2023· 24 citedOpen Access
Identification of sixteen novel candidate genes for late onset Parkinson’s disease
Molecular Neurodegeneration·2021· 83 citedOpen Access
Direct repression of <i>Nanog</i> and <i>Oct4</i> by OTX2 modulates the contribution of epiblast-derived cells to germline and somatic lineage
Development·2021· 14 citedOpen Access
Functional Antagonism between OTX2 and NANOG Specifies a Spectrum of Heterogeneous Identities in Embryonic Stem Cells
Stem Cell Reports·2017· 37 citedOpen Access
Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth
Science·2017· 226 cited
Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast
Cell Reports·2016· 72 citedOpen Access
Increased dopaminergic innervation in the brain of conditional mutant mice overexpressing Otx2: Effects on locomotor behavior and seizure susceptibility
Neuroscience·2014· 17 cited
Otx2 cell-autonomously determines dorsal mesencephalon versus cerebellum fate independently of isthmic organizing activity
Development·2013· 26 citedOpen Access
Otx2 is an intrinsic determinant of the embryonic stem cell state and is required for transition to a stable epiblast stem cell condition
Development·2012· 196 citedOpen Access
Otx2 selectively controls the neurogenesis of specific neuronal subtypes of the ventral tegmental area and compensates En1-dependent neuronal loss and MPTP vulnerability
Developmental Biology·2012· 44 citedOpen Access
<i>Otx</i> genes in neurogenesis of mesencephalic dopaminergic neurons
Developmental Neurobiology·2011· 19 citedOpen Access
The Role of Otx2 in Adult Mesencephalic–Diencephalic Dopaminergic Neurons
Molecular Neurobiology·2010· 38 citedOpen Access
Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP
Nature Neuroscience·2010· 118 citedOpen Access
A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei
Nature Neuroscience·2010· 102 citedOpen Access
Otx2 expression is restricted to dopaminergic neurons of the ventral tegmental area in the adult brain
The International Journal of Developmental Biology·2009· 82 cited
Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm
Mechanisms of Development·2009· 31 cited
The Role of Otx Genes in Progenitor Domains of Ventral Midbrain
Advances in experimental medicine and biology·2009· 3 cited
Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon
Development·2008· 102 citedOpen Access
Serotonin Hyperinnervation Abolishes Seizure Susceptibility in<i>Otx2</i>Conditional Mutant Mice
Journal of Neuroscience·2008· 27 citedOpen Access
N-Terminal Amino Acid Sequences of Intact and Cleaved Forms of Mung Bean Nuclease
Planta Medica·2008· 2 citedOpen Access
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Frequent Co-authors

Antonio Simeone(18), Dario Acampora(15), Daniela Omodei(11), Michela Di Salvio(8), Wolfgang Wurst(7), Nilima Prakash(5), Pietro Mancuso(5), Vincenzo Nigro(3), Nicola Modugno(2), Alessia Lombardi(2), Sara Pietracupa(2), Lynne Krohn(2), Arcomaria Garofalo(2), Carmine Tomasetti(2), Ian Chambers(2), Prem Prakash Tripathi(2), Yuri Bozzi(2), Eduardo Puelles(2), Chiara Di Malta(1), Diletta Siciliano(1)