Sasha Lazetic

Nkarta Therapeutics (United States) — United States

Immunology and Microbiology · Life Sciences

10h-index4.7kcitations21works0.02yr avg
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Research Topics

Immune Cell Function and Interaction(14), CAR-T cell therapy research(7), T-cell and B-cell Immunology(5), Cancer Cells and Metastasis(5), Cancer, Hypoxia, and Metabolism(3)

Publications21 total

Abstract A044: Screening and characterization of CD38 chimeric antigen receptors for the development of natural killer cell-based therapies
Cancer Immunology Research·2023· 1 cited
381 Large-scale expansion and engineering of human NK cells sourced from peripheral blood versus umbilical cord blood
Regular and Young Investigator Award Abstracts·2022· 2 citedOpen Access
Abstract 6004: Surveying surface antigen expression in multiple myeloma preclinical models
Cancer Research·2022
113 CISH gene-knockout anti-CD70-CAR NK cells demonstrate potent anti-tumor activity against solid tumor cell lines and provide partial resistance to tumor microenvironment inhibition
Regular and Young Investigator Award Abstracts·2021· 4 citedOpen Access
151 Potentiating the Large-Scale Expansion and Engineering of Peripheral Blood-Derived CAR NK Cells for Off-the-Shelf Application
Regular and Young Investigator Award Abstracts·2021· 1 citedOpen Access
128 KIR haplotype can inform donor selection production of allogeneic memory-like CAR NK cells for clinical application
Regular and Young Investigator Award Abstracts·2021· 1 citedOpen Access
127 Preclinical evaluation of NKX019, a CD19-targeting CAR NK Cell
Regular and Young Investigator Award Abstracts·2020· 6 citedOpen Access
Abstract B64: Coexpression of a CD19-OX40-CD3ζ CAR with membrane-bound IL-15 enhances natural killer cell function
Cancer Immunology Research·2020· 1 cited
Abstract 2304: Expanded and engineered NK cells upregulate expression of activation and survival genes associated with increased cytotoxicity and persistence
Immunology·2019
Abstract 2304: Expanded and engineered NK cells upregulate expression of activation and survival genes associated with increased cytotoxicity and persistence
Cancer Research·2019
A PTK7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions
Science Translational Medicine·2017· 154 cited
Abstract 1220: A novel PTK7-targeted antibody-drug conjugate eliminates tumor-initiating cells and induces sustained tumor regressions
Cancer Research·2016
Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors
Proceedings of the National Academy of Sciences·2012· 618 citedOpen Access
DLL4 Blockade Inhibits Tumor Growth and Reduces Tumor-Initiating Cell Frequency
Cell stem cell·2009· 397 citedOpen Access
Correction: Colorectal Cancer Stem Cells Are Enriched in Xenogeneic Tumors Following Chemotherapy
PLoS ONE·2008· 41 citedOpen Access
Colorectal Cancer Stem Cells Are Enriched in Xenogeneic Tumors Following Chemotherapy
PLoS ONE·2008· 572 citedOpen Access
The Lectin-like Receptor KLRE1 Inhibits Natural Killer Cell Cytotoxicity
The Journal of Experimental Medicine·2003· 27 citedOpen Access
Chimeric Co-stimulatory Molecules That Selectively Act through CD28 or CTLA-4 on Human T Cells
Journal of Biological Chemistry·2002· 22 citedOpen Access
Cutting Edge: Human 2B4, an Activating NK Cell Receptor, Recruits the Protein Tyrosine Phosphatase SHP-2 and the Adaptor Signaling Protein SAP
The Journal of Immunology·1999· 295 citedOpen Access
HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C
Nature·1998· 2.2k cited
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Frequent Co-authors

James Trager(10), Luxuan Buren(6), Kate Jamboretz(6), Ivan H. Chan(6), Scott J. Dylla(5), Ming-Hong Xie(5), Joseph H. Phillips(4), Lewis L. Lanier(4), Austin Gurney(4), John Lewicki(4), Jorge Aguilar(4), Chao Guo(4), Cécile Chartier(3), Inkyung Park(3), Kellie Pickell(3), Michael F. Clarke(3), Nafees Rahman(3), Yanying Fan(3), Hadia Lemar(3), Fumiko Axelrod(2)