Mario Grifantini

Università di Camerino — Italy

Biochemistry, Genetics and Molecular Biology · Life Sciences

30h-index2.7kcitations212works0.02yr avg
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Research Topics

Adenosine and Purinergic Signaling(60), Biochemical and Molecular Research(57), HIV/AIDS drug development and treatment(54), Synthesis and Characterization of Heterocyclic Compounds(34), Synthesis and Biological Evaluation(25)

Publications212 total

Adenosine receptors as promising targets for the management of ocular diseases
Medicinal Chemistry Research·2021· 20 citedOpen Access
Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists
UNC Libraries·2020· 4 citedOpen Access
Recent Progress in Histone Deacetylase Inhibitors as Anticancer Agents
Current Medicinal Chemistry·2018· 122 cited
Development of C-Methyl Branched Purine Ribonucleoside Analogs: Chemistry, Biological Activity and Therapeutic Potential
Current Medicinal Chemistry·2016· 4 cited
5′-<i>C</i>-Ethyl-tetrazolyl-<i>N</i><sup>6</sup>-Substituted Adenosine and 2-Chloro-adenosine Derivatives as Highly Potent Dual Acting A<sub>1</sub> Adenosine Receptor Agonists and A<sub>3</sub> Adenosine Receptor Antagonists
Journal of Medicinal Chemistry·2015· 24 citedOpen Access
From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: Synthesis and biological evaluation of valproic esters of 3′-C-methyladenosine
Bioorganic & Medicinal Chemistry Letters·2014· 6 citedOpen Access
N6/5’-DISUBSTITUTED ADENOSINE AND 2-CHLORO-ADENOSINE DERIVATIVES AS POTENT AND SELECTIVE A1 ADENOSINE RECEPTOR AGONISTS: SYNTHESIS, BINDING ASSAYS AND ANTINOCICEPTIVE ACTIVITY IN MICE
Unicam Scientific Publications (University of Camerino)·2014
SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITY OF NOVEL HYDRAZONE DERIVATIVES
Unicam Scientific Publications (University of Camerino)·2014
4’-TETRAZOLYL-ALKYL-N6-SUBSTITUTED ADENOSINE DERIVATIVES AS HIGHLY POTENT DUAL ACTING A1 ADENOSINE RECEPTOR AGONISTS AND A3 ADENOSINE RECEPTOR ANTAGONISTS
Unicam Scientific Publications (University of Camerino)·2014
NOVEL 2-SUBSTITUTED 2’/3’-C-METHYL-ADENOSINE DERIVATIVES: SYNTHESIS AND BIOLOGICAL EVALUATION AGAINST TRYPANOSOMA BRUCEI
Unicam Scientific Publications (University of Camerino)·2013
5’-CHLORO-5’-DEOXY-N6-SUBSTITUTED ADENOSINE DERIVATIVES: SYNTHESIS, ADENOSINE RECEPTOR AFFINITY AND ANTINOCICEPTIVE ACTIVITY
Unicam Scientific Publications (University of Camerino)·2013
A1 ADENOSINE RECEPTOR REGULATES ATP-MEDIATED MICROGLIAL ACTIVATION IN VIVO AND IN VITRO: ROLE IN THE SPINAL NEURONAL PLASTICITY IN NEUROPATHIC MICE
Unicam Scientific Publications (University of Camerino)·2013
5'-Chloro-5'-deoxy-(±)-ENBA, a Potent and Selective Adenosine A1 Receptor Agonist, Alleviates Neuropathic Pain in Mice Through Functional Glial and Microglial Changes without Affecting Motor or Cardiovascular Functions
Molecules·2012· 53 citedOpen Access
Bisphosphonate Derivatives of 2’-C-Methyl-, and 3’-C-Methyl-Adenosine as Ligands at P2Y1 and P2Y2 Receptors
Unicam Scientific Publications (University of Camerino)·2012
ADP- and ATP-mimetics derived from 2'(3')-C-methyladenosine as human P2Y1 and P2Y2 receptor ligands
Unicam Scientific Publications (University of Camerino)·2012
Epigenetic agents as an adjunct to active chempotherapy in hematological tumor cell lines
2012
Synthesis and biological evaluation of (methylene)bisphosphonatederivatives of 2’-C-methyl-, and 3’-C-methyl-adenosine
2012
Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3′-C-methyl-ribonucleosides as antitumor agents
European Journal of Medicinal Chemistry·2011· 12 citedOpen Access
Dual-target dimeric molecules with antitumor properties. Synthesis and biological activity of 3’-C-methyladenosine-valproates
Unicam Scientific Publications (University of Camerino)·2010
5'-CHLORO-5'-DEOXY-N6-(±)-endo-NORBORNYLADENOSINE, A POTENT AND HIGHLY SELECTIVE HUMAN A1 ADENOSINE RECEPTOR AGONIST, PREVENTS HYPERALGESIA/ALLODYNIA AND EARLY OVER-EXPRESSION OF PRO-APOPTOTIC AND PRO-INFLAMMATORY GENES IN A MICE MODEL OF NEUROPATHIC PAIN
Unicam Scientific Publications (University of Camerino)·2010
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Frequent Co-authors

Palmarisa Franchetti(41), Loredana Cappellacci(30), Gloria Cristalli(12), Riccardo Petrelli(12), Sauro Vittori(10), Karl‐Norbert Klotz(8), Sante Martelli(8), Hiremagalur N. Jayaram(7), Ippolito Antonini(7), Claudia Martini(6), Patrizia Vita(6), G. Cristalli(5), Francesco Claudi(5), Antonio Lavecchia(5), Giulio Lupidi(5), Martin J. Lohse(4), Paolo La Colla(4), Anna Giulia Loi(4), Barry Goldstein(4), Stefano Marchetti(4)