Evette S. Radisky

Jacksonville College — United States

Medicine · Health Sciences

39h-index5.0kcitations196works8.92yr avg
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Research Topics

Peptidase Inhibition and Analysis(66), Protease and Inhibitor Mechanisms(65), Enzyme Production and Characterization(34), Pancreatic and Hepatic Oncology Research(22), Cancer Cells and Metastasis(15)

Publications195 total

Therapeutic potential of inhibitors of gelatinases <scp>MMP</scp> ‐2 and <scp>MMP</scp> ‐9 for the treatment of breast cancer
FEBS Journal·2025Open Access
Modifying inhibitor specificity for homologous enzymes by machine learning
FEBS Journal·2025Open Access
Discovery of an autoinhibited conformation in mesotrypsin reveals a strategy for selective serine protease inhibition
Science Advances·2025Open Access
Directed evolution of metalloproteinase inhibitor TIMP-1 for selective inhibition of MMP-9 exploits catalytic and fibronectin domain interactions
Journal of Biological Chemistry·2025· 5 citedOpen Access
Abstract 5115: Engineered TIMP-1 for selective MMP-9 inhibition: A novel strategy to suppress breast cancer invasiveness
Cancer Research·2025
Matrix metalloproteinase-driven epithelial-mesenchymal transition: implications in health and disease
Journal of Translational Medicine·2025· 40 citedOpen Access
Engineered TIMP2 with narrow MMP-9 specificity is an effective inhibitor of invasion and proliferation of triple-negative breast cancer cells
Journal of Biological Chemistry·2024· 8 citedOpen Access
Improving Circulation Half-Life of Therapeutic Candidate N-TIMP2 by Unfolded Peptide Extension
Biomolecules·2024· 5 citedOpen Access
Improving Circulation Half-Life of Therapeutic Candidate N-TIMP2 by Unfolded Peptide Extension
2024· 1 citedOpen Access
Extracellular proteolysis in cancer: Proteases, substrates, and mechanisms in tumor progression and metastasis
Journal of Biological Chemistry·2024· 74 citedOpen Access
Abstract 1954 Deciphering Selectivity in Mesotrypsin Inhibition: Validating an allosteric mechanism through mutation and enzyme kinetics
Journal of Biological Chemistry·2024Open Access
Abstract 1740 Characterizing the role of matrix metalloproteinase-3 (MMP-3) in the pathogenesis of acute respiratory distress syndrome (ARDS)
Journal of Biological Chemistry·2024Open Access
Abstract 1734 Investigating the catalytic activity of PRSS23 as a novel serine protease in ovarian cancer
Journal of Biological Chemistry·2024Open Access
Abstract 1331 Engineering Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) Variants with Improved Binding Selectivity toward Matrix Metalloproteinase-9 (MMP-9) as potential protein therapeutics
Journal of Biological Chemistry·2024· 1 citedOpen Access
Abstract 1915 Allosteric inhibition of serine proteases: a case study with the pro-oncogenic enzyme mesotrypsin
Journal of Biological Chemistry·2024Open Access
Engineering Selective TIMPs Using a Counter-Selective Screening Strategy
Methods in molecular biology·2023· 2 citedOpen Access
Structure and computation-guided yeast surface display for the evolution of TIMP-based matrix metalloproteinase inhibitors
Frontiers in Molecular Biosciences·2023· 17 citedOpen Access
Insights into Affinity Improvement of an Engineered Tissue Inhibitor of Metalloproteinases from Molecular Dynamics Simulations
Journal of Pharmacology and Experimental Therapeutics·2023Open Access
Designed Loop Extension Followed by Combinatorial Screening Confers High Specificity to a Broad Matrix Metalloproteinase Inhibitor
Journal of Molecular Biology·2023· 16 citedOpen Access
Supplementary Table 1 from Tumor Cell–Derived MMP3 Orchestrates Rac1b and Tissue Alterations That Promote Pancreatic Adenocarcinoma
2023Open Access
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Frequent Co-authors

Derek C. Radisky(24), Alexandra Hockla(12), Christine Mehner(8), Alexei S. Soares(7), Erin Miller(6), Jyotica Batra(6), Niv Papo(6), Itay Cohen(5), Moh’d A. Salameh(5), Daniel E. Koshland(4), Aziza Nassar(4), Chia-Jung Karen Lu(3), Jessica Robinson(3), Alan P. Fields(3), Jason Shirian(3), Julia M. Shifman(3), Ann L. Oberg(3), Davitte Khauv(3), Miklós Sahin‐Tóth(3), Mina J. Bissell(2)