Gabriel Martinez Botella

Materials Science · Physical Sciences

6h-index247citations13works8.02yr avg
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Research Topics

Crystallization and Solubility Studies(6), X-ray Diffraction in Crystallography(6), Neuroscience and Neuropharmacology Research(5), Ion channel regulation and function(2), Receptor Mechanisms and Signaling(2)

Publications13 total

Small molecules restore mutant mitochondrial DNA polymerase activity
Nature·2025· 8 citedOpen Access
The novel persistent sodium current inhibitor PRAX‐562 has potent anticonvulsant activity with improved protective index relative to standard of care sodium channel blockers
Epilepsia·2022· 27 citedOpen Access
CCDC 1970299: Experimental Crystal Structure Determination
The Cambridge Structural Database·2019Open Access
CCDC 1970301: Experimental Crystal Structure Determination
The Cambridge Structural Database·2019Open Access
CCDC 1970297: Experimental Crystal Structure Determination
The Cambridge Structural Database·2019Open Access
CCDC 1970300: Experimental Crystal Structure Determination
The Cambridge Structural Database·2019Open Access
CCDC 1970298: Experimental Crystal Structure Determination
The Cambridge Structural Database·2019Open Access
CCDC 1970302: Experimental Crystal Structure Determination
The Cambridge Structural Database·2019Open Access
Neuroactive Steroid <i>N</i>-Methyl-<scp>d</scp>-aspartate Receptor Positive Allosteric Modulators: Synthesis, SAR, and Pharmacological Activity
Journal of Medicinal Chemistry·2019· 16 citedOpen Access
Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1 <i>H</i> -pyrazol-1′-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid) <sub>A</sub> Receptor
Journal of Medicinal Chemistry·2017· 119 citedOpen Access
Anticonvulsant profile of the neuroactive steroid, SGE-516, in animal models
Epilepsy Research·2017· 23 cited
Abiraterone Acetate (Zytiga®): An Inhibitor of CYP17 as a Therapeutic for Castration‐Resistant Prostate Cancer
2016· 1 cited
Neuroactive Steroids. 1. Positive Allosteric Modulators of the (γ-Aminobutyric Acid) <sub>A</sub> Receptor: Structure–Activity Relationships of Heterocyclic Substitution at C-21
Journal of Medicinal Chemistry·2015· 53 cited

Frequent Co-authors

Francesco G. Salituro(10), Boyd L. Harrison(10), Michael A. Ackley(10), James Doherty(10), Albert J. Robichaud(10), Zhu Bai(9), Ethan Hoffmann(9), Andrew M. Griffin(9), Daniel S. La(7), Tatiana M. Kazdoba(7), Michael Lewis(7), Michael C. Quirk(7), Jing Dai(5), Gabriel M. Belfort(3), Jing Dai(3), Richard T. Beresis(2), Carlos M. Loya(2), Alison L. Althaus(2), Scott Grossman(2), María‐Jesús Blanco(1)