Tatiana M. Kazdoba

Sage Therapeutics (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

19h-index1.7kcitations35works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(8), Neuroscience and Neuropharmacology Research(7), Autism Spectrum Disorder Research(6), Crystallization and Solubility Studies(6), X-ray Diffraction in Crystallography(6)

Publications35 total

Pharmacological characterization of SAGE‐718, a novel positive allosteric modulator of N‐methyl‐<scp>d</scp>‐aspartate receptors
British Journal of Pharmacology·2023· 13 citedOpen Access
SAGE-718: A First-in-Class<i>N</i>-Methyl-<scp>d</scp>-Aspartate Receptor Positive Allosteric Modulator for the Potential Treatment of Cognitive Impairment
Journal of Medicinal Chemistry·2022· 39 citedOpen Access
Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABAA receptor positive allosteric modulator
Neuropharmacology·2020· 121 citedOpen Access
CCDC 1970299: Experimental Crystal Structure Determination
The Cambridge Structural Database·2019Open Access
CCDC 1970301: Experimental Crystal Structure Determination
The Cambridge Structural Database·2019Open Access
CCDC 1970297: Experimental Crystal Structure Determination
The Cambridge Structural Database·2019Open Access
CCDC 1970300: Experimental Crystal Structure Determination
The Cambridge Structural Database·2019Open Access
CCDC 1970298: Experimental Crystal Structure Determination
The Cambridge Structural Database·2019Open Access
CCDC 1970302: Experimental Crystal Structure Determination
The Cambridge Structural Database·2019Open Access
Neuroactive Steroid <i>N</i>-Methyl-<scp>d</scp>-aspartate Receptor Positive Allosteric Modulators: Synthesis, SAR, and Pharmacological Activity
Journal of Medicinal Chemistry·2019· 16 citedOpen Access
Hypothesis‐driven investigations of diverse pharmacological targets in two mouse models of autism
Autism Research·2019· 39 citedOpen Access
R-Baclofen Reverses Cognitive Deficits and Improves Social Interactions in Two Lines of 16p11.2 Deletion Mice
Neuropsychopharmacology·2017· 93 citedOpen Access
Differential roles for Akt and mTORC1 in the hypertrophy of Pten mutant neurons, a cellular model of brain overgrowth disorders
Neuroscience·2017· 21 cited
Evaluation of the neuroactive steroid ganaxolone on social and repetitive behaviors in the BTBR mouse model of autism
Psychopharmacology·2015· 57 citedOpen Access
Behavioral phenotypes of genetic mouse models of autism
Genes Brain & Behavior·2015· 183 citedOpen Access
Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics
Current topics in behavioral neurosciences·2015· 174 citedOpen Access
Modeling fragile X syndrome in the &lt;i&gt;Fmr1&lt;/i&gt; knockout mouse
Intractable & Rare Diseases Research·2014· 229 citedOpen Access
Antagonism of the adenosine A2A receptor attenuates akathisia-like behavior induced with MP-10 or aripiprazole in a novel non-human primate model
Pharmacology Biochemistry and Behavior·2013· 13 cited
Dab1 Is Required for Synaptic Plasticity and Associative Learning
Journal of Neuroscience·2013· 87 citedOpen Access
Targeting mTOR as a novel therapeutic strategy for traumatic CNS injuries
Drug Discovery Today·2012· 66 citedOpen Access
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Frequent Co-authors

Michael A. Ackley(10), Ethan Hoffmann(10), Albert J. Robichaud(10), Michael C. Quirk(10), James Doherty(10), Francesco G. Salituro(9), Lynn A. Hyde(9), Michael Lewis(9), Gabriella D’Arcangelo(8), Zhu Bai(8), Boyd L. Harrison(8), Eric M. Parker(7), Daniel S. La(7), Gabriel Martinez Botella(7), Andrew M. Griffin(7), Jacqueline N. Crawley(6), Beth Crowell(6), Robert A. Del Vecchio(6), Frank A. Middleton(6), Russell W. Brown(6)