Dennis Wetzl

Roche (Switzerland) — Switzerland

Biochemistry, Genetics and Molecular Biology · Life Sciences

10h-index426citations20works6.82yr avg
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Research Topics

Enzyme Catalysis and Immobilization(15), Microbial Metabolic Engineering and Bioproduction(6), Asymmetric Hydrogenation and Catalysis(4), Biochemical and Molecular Research(3), Innovative Microfluidic and Catalytic Techniques Innovation(2)

Publications20 total

Data-Driven Construction of an Imine Reductase Library Capable of Broad-Scope Reductive Amination at Equimolar Substrate Concentrations
2026Open Access
Data-Driven Construction of an Imine Reductase Library Capable of Broad-Scope Reductive Amination at Equimolar Substrate Concentrations
2024Open Access
Structure-Guided Discovery of <i>cis</i>-Hexahydro-pyrido-oxazinones as Reversible, Drug-like Monoacylglycerol Lipase Inhibitors
Journal of Medicinal Chemistry·2024· 7 citedOpen Access
Biocatalyst Immobilization and Process Intensification: Production of (<i>S</i>)-Piperazine-2-carboxylic Acid Dihydrochloride
Organic Process Research & Development·2024· 7 cited
Effective engineering of a ketoreductase for the biocatalytic synthesis of an ipatasertib precursor
Communications Chemistry·2024· 20 citedOpen Access
Screening methods for enzyme-mediated alcohol oxidation
Scientific Reports·2022· 10 citedOpen Access
Cover Feature: Multi‐faceted Set‐up of a Diverse Ketoreductase Library Enables the Synthesis of Pharmaceutically‐relevant Secondary Alcohols (6/2021)
ChemCatChem·2021Open Access
Multi‐faceted Set‐up of a Diverse Ketoreductase Library Enables the Synthesis of Pharmaceutically‐relevant Secondary Alcohols
ChemCatChem·2020· 25 cited
Asymmetric Biocatalytic Synthesis of 1‐Aryltetrahydro‐β‐carbolines Enabled by “Substrate Walking”
Chemistry - A European Journal·2020· 23 citedOpen Access
From lab to large scale – Industrial biocatalysis from an SIBC perspective
New Biotechnology·2018· 1 cited
Extended Catalytic Scope of a Well‐Known Enzyme: Asymmetric Reduction of Iminium Substrates by Glucose Dehydrogenase
ChemBioChem·2017· 50 cited
Asymmetric Biocatalytic Reduction of Cyclic Imines: Design and Application of a Tailor-Made Whole-Cell Catalyst
Heterocycles·2017· 17 citedOpen Access
Process Development of Imine Reductase‐Catalyzed Enantioselective Synthesis of Cyclic Amines
Chemie Ingenieur Technik·2016· 1 cited
Back Cover: Asymmetric Reductive Amination of Ketones Catalyzed by Imine Reductases (ChemCatChem 12/2016)
ChemCatChem·2016
Asymmetric Reductive Amination of Ketones Catalyzed by Imine Reductases
ChemCatChem·2016· 131 cited
α‐Hydroxylation of Carboxylic Acids Catalyzed by Taurine Dioxygenase
ChemCatChem·2016· 11 cited
Inside Back Cover: Expanding the Imine Reductase Toolbox by Exploring the Bacterial Protein‐Sequence Space (ChemBioChem 12/2015)
ChemBioChem·2015
Expanding the Imine Reductase Toolbox by Exploring the Bacterial Protein‐Sequence Space
ChemBioChem·2015· 107 cited
Untersuchungen zur Bestimmung des inhärenten katalytischen Potentials von Metall-bindenden Enzymen
OPUS Publication Server of the University of Stuttgart (University of Stuttgart)·2014Open Access
Thiol-functionalization of acrylic ester monomers catalyzed by immobilized Humicola insolens cutinase
Enzyme and Microbial Technology·2012· 16 cited

Frequent Co-authors

Hans Iding(16), Steven P. Hanlon(7), Michael Müller(5), Beat Wirz(5), Kurt Puentener(4), Nicolas Sandon(3), Michael Niklaus(3), Rebecca Buller(3), Joerg H. Schrittwieser(3), Bernd Kuhn(3), Bettina M. Nestl(3), Irene Marzuoli(3), Martin Gand(2), Alfred Ross(2), Hubertus Müller(2), Philipp Matzel(2), Matthias Höhne(2), Marco Berrera(2), Dan Fishlock(2), Martin Ebeling(2)