Simon Blake

Medicine · Health Sciences

21h-index2.1kcitations37works0.02yr avg
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Research Topics

Osteoarthritis Treatment and Mechanisms(12), Bone Metabolism and Diseases(7), Rheumatoid Arthritis Research and Therapies(6), Cell Adhesion Molecules Research(6), Monoclonal and Polyclonal Antibodies Research(4)

Publications37 total

Mechanical injury potentiates proteoglycan catabolism induced by interleukin‐6 with soluble interleukin‐6 receptor and tumor necrosis factor α in immature bovine and adult human articular cartilage
Arthritis & Rheumatism·2009· 99 cited
Resistin is elevated following traumatic joint injury and causes matrix degradation and release of inflammatory cytokines from articular cartilage in vitro
Osteoarthritis and Cartilage·2008· 120 citedOpen Access
Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13
Arthritis Research & Therapy·2008· 94 citedOpen Access
103 MEASUREMENT AND CORRELATION OF INFLAMMATORY MEDIATORS IN SERUM AND SYNOVIAL FLUID FROM A CROSS-SECTIONAL OSTEOARTHRITIS COHORT
Osteoarthritis and Cartilage·2007Open Access
119 RELATIONSHIPS AMONG AND DISCRIMINATORY ABILITY OF INFLAMMATORY MEDIATORS IN SERUM AND SYNOVIAL FLUID IN A CROSS-SECTIONAL OSTEOARTHRITIS COHORT
Osteoarthritis and Cartilage·2007
A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys
Bone·2006· 136 cited
A53 MECHANICAL INJURY POTENTIATES THE COMBINED EFFECTS OF TNF-α AND IL-6/sIL-6R ON PROTEOGLYCAN CATABOLISM IN BOVINE CARTILAGE
Osteoarthritis and Cartilage·2006
P97 HYALURONAN-LINKED INTER-á-TRYPSIN INHIBITOR HEAVY CHAIN (SHAP), INTERLEUKIN 8, MMP-3 AND HYALURONAN IN HUMAN SYNOVIAL FLUID AND SERUM IN OSTEOARTHRITIS, JOINT INJURY AND INFLAMMATION
Osteoarthritis and Cartilage·2006Open Access
Azepanone-Based Inhibitors of Human Cathepsin L
Journal of Medicinal Chemistry·2005· 25 citedOpen Access
Pharmacological Potential of p38 MAPK Inhibitors
Handbook of experimental pharmacology·2005· 7 cited
What next for rheumatoid arthritis therapy?
Current Opinion in Pharmacology·2004· 10 cited
Ultrastructural quantification of cell death after injurious compression of bovine calf articular cartilage
Osteoarthritis and Cartilage·2003· 70 citedOpen Access
Potent and selective cathepsin L inhibitors do not inhibit human osteoclast resorption in vitro.
Journal of Biological Chemistry·2003Open Access
Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: Interaction with exogenous cytokines
Arthritis & Rheumatism·2003· 176 cited
A potent small molecule, nonpeptide inhibitor of cathepsin K (SB 331750) prevents bone matrix resorption in the ovariectomized rat
Bone·2002· 78 cited
Outcome Analysis of Patients with Acute Pancreatitis by Using an Artificial Neural Network
Academic Radiology·2002· 48 cited
Potent and Selective Inhibition of Human Cathepsin K Leads to Inhibition of Bone Resorption In Vivo in a Nonhuman Primate
Journal of Bone and Mineral Research·2001· 153 cited
PB63 Floating section immunocytochemistry: An alternative method for staining articular cartilage
Osteoarthritis and Cartilage·2001Open Access
Potent and Selective Cathepsin L Inhibitors Do Not Inhibit Human Osteoclast Resorption in Vitro
Journal of Biological Chemistry·2001· 32 citedOpen Access
Azepanone-Based Inhibitors of Human and Rat Cathepsin K
Journal of Medicinal Chemistry·2001· 102 citedOpen Access
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Frequent Co-authors

Michael W. Lark(16), Ian E. James(14), Maxine Gowen(11), Daniel F. Veber(7), Robert W. Marquis(7), Tim Hardingham(7), George B. Stroup(6), Alan J. Grodzinsky(5), Yu Ru(5), Thaddeus A. Tomaszek(5), Dennis S. Yamashita(5), Catherine J. Gress(5), Alison M. Badger(4), Sanjay Kumar(4), Shing Mei Hwang(4), Hye-Ja Oh(4), Stefan Lohmander(4), Robert A. Dodds(4), J Lewthwaite(4), Brian E. Henderson(4)