Harald Hübner

Friedrich-Alexander-Universität Erlangen-Nürnberg — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

42h-index7.9kcitations240works5.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(147), Neuropeptides and Animal Physiology(67), Chemical Synthesis and Analysis(55), Pharmacological Receptor Mechanisms and Effects(31), Neurotransmitter Receptor Influence on Behavior(24)

Publications240 total

The Role of Intrinsically Disordered Domains in Regulating G Protein-Coupled Receptor Signaling
Journal of the American Chemical Society·2025
The role of intrinsically disordered domains in regulating G protein coupled receptor signaling
2025· 1 citedOpen Access
Mechanism and function of GPR3 regulated by a negative allosteric modulator
Nature Communications·2025· 2 citedOpen Access
Discovery of a functionally selective serotonin receptor (5-HT <sub>1A</sub> R) agonist for the treatment of pain
Science Advances·2025· 5 citedOpen Access
Towards "unmakable" psychedelics: SAR exploration of psilocin analogs obtained by a HATU-mediated amide coupling strategy
European Journal of Medicinal Chemistry Reports·2025· 1 citedOpen Access
99mTc-Labeled Diarylpyrazoles for Single-Emission Computer Tomography Imaging of Neurotensin Receptor-Positive Tumors: A Comparative Preclinical Study
Pharmaceutics·2025Open Access
Synthesis and Characterization of Photoswitchable Covalent Ligands for the β <sub>2</sub> ‐Adrenoceptor
Angewandte Chemie·2025Open Access
Synthesis and Characterization of Photoswitchable Covalent Ligands for the β <sub>2</sub> ‐Adrenoceptor
Angewandte Chemie International Edition·2025· 1 citedOpen Access
Structure and dynamics determine G protein coupling specificity at a class A GPCR
Science Advances·2025· 23 citedOpen Access
Neurotensin(8-13) analogs targeting NTS1 and NTS2 receptors: A comparative in vitro and molecular modeling study
Current Research in Biotechnology·2025· 1 citedOpen Access
A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR
Nature Communications·2024· 31 citedOpen Access
Development of Neurotensin(8-13) Analogs as Potent NTS1/NTS2 Receptor Ligands with Enhanced Effects on a Mouse Model of Parkinson’s Disease
2024Open Access
Dually Labeled Neurotensin NTS<sub>1</sub>R Ligands for Probing Radiochemical and Fluorescence-Based Binding Assays
Journal of Medicinal Chemistry·2024· 3 citedOpen Access
Heteroaryl derivatives of suvorexant as OX1R selective PET ligand candidates: Cu-mediated 18F-fluorination of boroxines, in vitro and initial in vivo evaluation
EJNMMI Research·2024· 3 citedOpen Access
Design, Synthesis, and Characterization of New δ Opioid Receptor-Selective Fluorescent Probes and Applications in Single-Molecule Microscopy of Wild-Type Receptors
Journal of Medicinal Chemistry·2024· 4 citedOpen Access
Structure-guided discovery of orexin receptor-binding PET ligands
Bioorganic & Medicinal Chemistry·2024· 7 citedOpen Access
Heteroaryl derivatives of suvorexant as OX1R selective PET ligand candidates: Cu-mediated 18F-fluorination of boroxines, in vitro and initial in vivo evaluation
2024· 2 citedOpen Access
Structure-guided discovery of orexin receptor-binding PET ligands
2024· 3 citedOpen Access
Development of a Fluorescent Ligand for the Intracellular Allosteric Binding Site of the Neurotensin Receptor 1
ACS Pharmacology & Translational Science·2024· 12 citedOpen Access
Intracellular binding pocket revealed in the human bitter taste receptor TAS2R14
2024· 4 citedOpen Access
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Frequent Co-authors

Peter Gmeiner(47), Stefan Löber(9), Brian K. Kobilka(9), Jonas Kaindl(7), Nuška Tschammer(6), Jürgen Einsiedel(5), Ralf C. Kling(4), Brian K. Shoichet(4), Olaf Prante(4), Ashutosh Banerjee(4), Aashish Manglik(3), Laura Bettinetti(3), Wolfgang Utz(3), Jun Xu(3), Mary J. Clark(3), Kunio Hirata(3), Roger K. Sunahara(3), Carsten Hocke(3), Torsten Kuwert(3), Christine Hiller(3)