Leah C. Byrne

University of Pittsburgh — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index2.8kcitations85works2.82yr avg
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Research Topics

Retinal Development and Disorders(46), Virus-based gene therapy research(27), CRISPR and Genetic Engineering(21), Retinal Diseases and Treatments(8), Photoreceptor and optogenetics research(7)

Publications85 total

A mobile system for whole eye perfusion supporting retinal function and surgery
Frontiers in Bioengineering and Biotechnology·2026Open Access
Novel photoreceptor-specific promoters for gene therapy in mid- to late-stage retinal degeneration
Molecular Therapy·2025· 2 citedOpen Access
Machine learning identification of enhancers in the rhesus macaque genome
Neuron·2025· 7 citedOpen Access
Tppp3 is a novel molecule for retinal ganglion cell identification and optic nerve regeneration
Acta Neuropathologica Communications·2024· 4 citedOpen Access
Cell Type Specific Enhancers for Dorsolateral Prefrontal Cortex
2024· 2 citedOpen Access
Retinal Explant Culture from Mouse, Human, and Nonhuman Primates and Its Applications in Vision Research
Methods in molecular biology·2024· 4 citedOpen Access
In Vivo Imaging of Rodent Retina in Retinal Disease
Methods in molecular biology·2024
Chromatographic Purification and Polishing of AAV Particles
Methods in molecular biology·2024· 3 cited
Can Viruses Be Used to Make People Healthy?
Frontiers for Young Minds·2023Open Access
PRPF31-retinitis pigmentosa: Challenges and opportunities for clinical translation
Vision Research·2023· 15 citedOpen Access
Adaptable three-pin skull clamp for large animal research
HardwareX·2023Open Access
Developing New Vectors for Retinal Gene Therapy
Cold Spring Harbor Perspectives in Medicine·2023· 11 citedOpen Access
Adaptable Three-Pin Skull Clamp for Large Animal Research
SSRN Electronic Journal·2023Open Access
Gene augmentation prevents retinal degeneration in a CRISPR/Cas9-based mouse model of PRPF31 retinitis pigmentosa
Nature Communications·2022· 28 citedOpen Access
Modeling PRPF31 retinitis pigmentosa using retinal pigment epithelium and organoids combined with gene augmentation rescue
npj Regenerative Medicine·2022· 70 citedOpen Access
Quantitative single-cell transcriptome-based ranking of engineered AAVs in human retinal explants
Molecular Therapy — Methods & Clinical Development·2022· 13 citedOpen Access
Machine learning sequence prioritization for cell type-specific enhancer design
eLife·2022· 28 citedOpen Access
Targeting ON-bipolar cells by AAV gene therapy stably reverses <i>LRIT3</i> -congenital stationary night blindness
Proceedings of the National Academy of Sciences·2022· 28 citedOpen Access
Author response: Machine learning sequence prioritization for cell type-specific enhancer design
2022Open Access
Transcriptional and anatomical diversity of medium spiny neurons in the primate striatum
Current Biology·2021· 89 citedOpen Access
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Frequent Co-authors

John G. Flannery(19), David V. Schaffer(13), Bilge Esin Öztürk(12), William R. Stauffer(11), Meike Visel(10), José‐Alain Sahel(9), Andreas R. Pfenning(9), Deniz Dalkara(8), Jing He(8), Zhouhuan Xi(8), Michael Kleyman(6), Aydin Alikaya(6), William A. Beltran(6), Morgan Wirthlin(5), Kenneth N. Fish(5), Valérie Dufour(5), Geoffrey K. Aguirre(5), Timothy P. Day(4), Jianjiao Chen(4), Kathryn M. Rothenhoefer(4)