Giridhara R. Jayandharan

Indian Institute of Technology Kanpur — India

Biochemistry, Genetics and Molecular Biology · Life Sciences

31h-index3.3kcitations111works1.52yr avg
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Research Topics

Virus-based gene therapy research(54), RNA Interference and Gene Delivery(33), Hemophilia Treatment and Research(31), CRISPR and Genetic Engineering(23), Platelet Disorders and Treatments(16)

Publications111 total

An engineered AAVrh10 vector containing an optimized factor IX transgene improves therapeutic response during hemophilia b gene therapy
Blood·2025
Suppressing microtubule detyrosination augments adeno-associated virus 2 endosomal escape and gene delivery
Journal of Cell Science·2025· 1 citedOpen Access
Suppressing microtubule detyrosination augments AAV2 endosomal escape and gene delivery
2025Open Access
AAV-mediated combination gene therapy of inducible Caspase 9 and miR-199a-5p is therapeutic in hepatocellular carcinoma
Cancer Gene Therapy·2024· 1 cited
Development of an Optimized Promoter System for Exosomal and Naked AAV Vector-Based Suicide Gene Therapy in Hepatocellular Carcinoma
ACS Omega·2024· 4 citedOpen Access
<scp>AAV</scp> mediated repression of Neat1 <scp>lncRNA</scp> combined with <scp>F8</scp> gene augmentation mitigates pathological mediators of joint disease in haemophilia
Journal of Cellular and Molecular Medicine·2024· 2 citedOpen Access
AAV mediated genome engineering with a bypass coagulation factor alleviates the bleeding phenotype in a murine model of hemophilia B
Thrombosis Research·2024· 1 cited
Generation of two induced pluripotent stem cell lines (LVPEIi004-A and LVPEIi005-A) from probands with Leber Congenital Amaurosis 2 (LCA2) and harboring mutations in RPE65
Stem Cell Research·2024· 3 citedOpen Access
Inducible caspase 9-mediated suicide gene therapy using AAV6 vectors in a murine model of breast cancer
Molecular Therapy — Methods & Clinical Development·2023· 9 citedOpen Access
Intraarticular Delivery of AAV5-Mir-125a-5p Regulates Key Molecular Mediators of Hemophilic Arthropathy
Blood·2023Open Access
Targeted delivery of miR125a-5p and human Factor VIII attenuates molecular mediators of hemophilic arthropathy
Thrombosis Research·2023· 8 cited
Implementation of a gene therapy education initiative by the ASGCT and Muhimbili University of Health and Allied Sciences
Molecular Therapy·2023· 3 citedOpen Access
Potential role of long non‐coding <scp>RNA <i>H19</i></scp> and <i>Neat1</i> in haemophilic arthropathy
Journal of Cellular and Molecular Medicine·2023· 5 citedOpen Access
Polyketal-based nanocarriers: A new class of stimuli-responsive delivery systems for therapeutic applications
European Polymer Journal·2022· 1 cited
Gene therapy for female infertility: A farfetched dream or reality?
Cell Reports Medicine·2022· 3 citedOpen Access
Safety of Adeno-associated virus-based vector-mediated gene therapy—impact of vector dose
Cancer Gene Therapy·2022· 53 citedOpen Access
Vector engineering, strategies and targets in cancer gene therapy
Cancer Gene Therapy·2021· 46 cited
Evaluation of the Anticancer Activity of pH-Sensitive Polyketal Nanoparticles for Acute Myeloid Leukemia
Molecular Pharmaceutics·2021· 5 cited
Enhanced Transgene Expression from Recombinant Single-Stranded D-Sequence-Substituted Adeno-Associated Virus Vectors in Human Cell Lines In Vitro and in Murine Hepatocytes In Vivo
UNC Libraries·2020· 2 citedOpen Access
Adeno-Associated Virus Serotype 6 Capsid Tyrosine-to-Phenylalanine Mutations Improve Gene Transfer to Skeletal Muscle
UNC Libraries·2020· 4 citedOpen Access
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Frequent Co-authors

Alok Srivastava(19), Arun Srivastava(15), Mammen Chandy(10), Dwaipayan Sen(9), Sukesh C. Nair(9), Zhong Li(8), Baozheng Li(7), George Aslanidi(7), Chen Ling(7), Shaji R Velayudhan(7), Auro Viswabandya(7), Shubham Maurya(6), Balaji Balakrishnan(5), Wenqin Ma(5), Bertin Mary(5), Biju George(5), Roland W. Herzog(4), Nusrat Khan(4), Sangeetha Hareendran(4), Ruchita Selot(4)