Sylvain Célanire

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index780citations36works2.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(11), Mast cells and histamine(11), Neuroscience and Neuropharmacology Research(8), Coordination Chemistry and Organometallics(6), Asymmetric Synthesis and Catalysis(4)

Publications36 total

Therapeutic indications for HDAC6 inhibitors in the peripheral and central nervous disorders
Expert Opinion on Therapeutic Targets·2024· 2 citedOpen Access
Noise-Induced Hearing Loss in Mice: Effects of High and Low Levels of Noise Trauma in CBA Mice
2018· 12 cited
Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells
Neuropharmacology·2015· 30 citedOpen Access
Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage
Molecular Brain·2015· 28 citedOpen Access
Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 – present)
Expert Opinion on Therapeutic Patents·2014· 28 cited
Small Molecule Therapeutics for Schizophrenia
Topics in medicinal chemistry·2014· 17 cited
Characterization of the Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 ADX88178 in Rodent Models of Neuropsychiatric Disorders
Journal of Pharmacology and Experimental Therapeutics·2014· 69 citedOpen Access
Glutamate Receptor Modulators as Emergent Therapeutic Agents in the Treatment of Parkinson’s Disease
2013
Lead Optimization of Thiazolo[5,4‐<i>c</i>]piperidines: 3‐Cyclobutoxy Linker as a Key Spacer for H<sub>3</sub>R Inverse Agonists
ChemMedChem·2012· 3 cited
Recent advances in the drug discovery of metabotropic glutamate receptor 4 (mGluR4) activators for the treatment of CNS and non-CNS disorders
Expert Opinion on Drug Discovery·2012· 37 cited
mGluR2 Activators and mGluR5 Blockers Advancing in the Clinic for Major CNS Disorders
Annual reports in medicinal chemistry·2012· 6 cited
Characterization of an mGluR2/3 Negative Allosteric Modulator in Rodent Models of Depression
Journal of Neurogenetics·2011· 75 cited
Acetamide Scanning around Bicyclic Thiazoles: SAR at the H<sub>3</sub> Receptor
ChemMedChem·2011· 7 cited
Histamine H3 receptor ligands with a 3-cyclobutoxy motif: a novel and versatile constraint of the classical 3-propoxy linker
MedChemComm·2010· 10 cited
Phenyl‐oxazoles, a New Family of Inverse Agonists at the H<sub>3</sub> Histamine Receptor
ChemMedChem·2009· 15 cited
Discovery of a New Class of Non‐imidazole Oxazoline‐Based Histamine H<sub>3</sub> Receptor (H<sub>3</sub>R) Inverse Agonists
ChemMedChem·2009· 11 cited
Drug Discovery: From Hits to Clinical Candidates
2008· 1 cited
H3 Receptor Target: Past, Present, and Future Perspectives from Worldwide H3 Experts
2008
Drug Discovery
2008· 14 cited
H3 Receptor Target
2008
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Frequent Co-authors

Michel Gillard(7), Sonia Poli(6), B. Christophe(6), Patrice Talaga(5), Rob Leurs(5), P. RIBEREAU(5), G. QUEGUINER(5), Frédéric Denonne(5), Christel Delaunoy(5), Nathalie Van houtvin(5), Laurent Provins(5), Maikel Wijtmans(4), Iwan J. P. de Esch(4), Henk Timmerman(4), Florence Lebon(4), Christophe Pain(4), Gérald Guillaumet(4), Benoı̂t Joseph(4), Véronique Durieu(4), Yves Lamberty(4)