Alexander J. Smith

Guy's Hospital — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

65h-index15.9kcitations225works3.62yr avg
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Research Topics

Retinal Development and Disorders(98), Retinal Diseases and Treatments(40), Photoreceptor and optogenetics research(29), Virus-based gene therapy research(27), Drug Transport and Resistance Mechanisms(14)

Publications225 total

TMIC-78. Aquaporin-4 loss in astrocytes drives glioblastoma-associated cerebral edema and alters the tumor immune microenvironment
Neuro-Oncology·2025Open Access
Human macula formation involves two waves of retinoic acid suppression via CYP26A1 that modulate cell cycle exit and cone subtype specification
Stem Cell Reports·2025· 1 citedOpen Access
Characterization of Bruch's Membrane Formation in Human Fetal Retina and De Novo Membrane Synthesis by hPSC-Derived Retinal Pigment Epithelium
Investigative Ophthalmology & Visual Science·2025Open Access
Stromal Gene Therapy Mediates Prolonged Protection Against Corneal Neovascularization Induced by an Aggressive Angiogenic Insult
Human Gene Therapy·2025
Human cone photoreceptor transplantation stimulates remodeling and restores function in AIPL1 model of end-stage Leber congenital amaurosis
Stem Cell Reports·2025· 3 citedOpen Access
Gene therapy in children with AIPL1-associated severe retinal dystrophy: an open-label, first-in-human interventional study
The Lancet·2025· 13 citedOpen Access
Eltrombopag Added to Standard Immunosuppressive Treatment Improves Long-Term Outcomes As Front-Line Therapy for Severe Aplastic Anemia: Final 2-Year Analysis of EBMT-Saawp Race Study
Blood·2024· 1 cited
Human macula formation involves two waves of retinoic acid suppression via <i>CYP26A1</i> that modulate cell cycle exit and cone subtype specification
2024Open Access
Correction: Development of an optimized AAV2/5 gene therapy vector for Leber congenital amaurosis owing to defects in RPE65
Gene Therapy·2024Open Access
Author Correction: Restoration of vision after transplantation of photoreceptors
Nature·2024· 2 citedOpen Access
A protocol for isolation and culturing of mouse primary postmitotic photoreceptors and isolation of extracellular vesicles
STAR Protocols·2024Open Access
Large molecules from the cerebrospinal fluid enter the optic nerve but not the retina of mice
Fluids and Barriers of the CNS·2024· 23 citedOpen Access
Role of HIF1α and HIF2α in Cre Recombinase–Induced Retinal Pigment Epithelium Pathology and Its Secondary Effect on Choroidal Neovascularization
American Journal Of Pathology·2023· 2 citedOpen Access
First-in-Human Gene Therapy Trial of AAV8-hCARp.hCNGB3 in Adults and Children With CNGB3-associated Achromatopsia
American Journal of Ophthalmology·2023· 45 citedOpen Access
Gene Supplementation in Mice Heterozygous for the D477G RPE65 Variant Implicated in Autosomal Dominant Retinitis Pigmentosa
Human Gene Therapy·2023· 5 citedOpen Access
Editorial: Mechanisms and consequences of Aquaporin-4 redistribution in neurological disease
Frontiers in Cellular Neuroscience·2023· 3 citedOpen Access
Extracellular vesicles in the retina - putative roles in physiology and disease
Frontiers in Molecular Neuroscience·2023· 14 citedOpen Access
THE WIDOWHOOD EFFECT IN COMPLEX SERIOUS ILLNESS: THE IMPACT OF SPOUSAL DEATH ON MORTALITY IN DEMENTIA
Innovation in Aging·2022Open Access
Letter to the editor: ‘Emerging gene therapy products for <i>RPGR</i>-associated X-linked retinitis pigmentosa’
Expert Opinion on Emerging Drugs·2022· 1 cited
Spatiotemporal control of actomyosin contractility by MRCKβ signaling drives phagocytosis
The Journal of Cell Biology·2022· 16 citedOpen Access
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Frequent Co-authors

Robin R. Ali(28), James Bainbridge(15), Yanaí Durán(12), R. A. Pearson(11), Emma L. West(9), Piet Borst(8), Jane C. Sowden(8), Anai Gonzalez-Cordero(7), Kamaljit S. Balaggan(5), Adrian J. Thrasher(5), Anastasios Georgiadis(5), Debbie Goh(5), Robert D. Sampson(5), Joana Ribeiro(5), Susie E. Barker(4), Ronald P.J. Oude Elferink(4), Amanda C. Barber(4), Matteo Rizzi(4), Ulrich F. O. Luhmann(4), Arifa Naeem(4)