S. Deferme

Medicine · Health Sciences

14h-index925citations39works0.02yr avg
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Research Topics

Drug Transport and Resistance Mechanisms(13), HIV/AIDS drug development and treatment(8), Drug Solubulity and Delivery Systems(6), Ginger and Zingiberaceae research(5), Gastroesophageal reflux and treatments(4)

Publications39 total

Permeability Measurement
2016· 5 cited
Automated blood sampling in drug discovery and development
2011· 2 cited
Oral drug absorption: permeability measurement
2010
Drug Absorption Studies: In Situ, In Vitro and In Silico Models
2008· 90 cited
In Vitro Screening Models to Assess Intestinal Drug Absorption and Metabolism
2007· 62 cited
Characterization of fasted-state human intestinal fluids collected from duodenum and jejunum
Journal of Pharmacy and Pharmacology·2006· 175 cited
Combination of the candidate microbicide CADA, an entry inhibitor that specifically targets the cellular CD4 receptor, and cellulose acetate 1,2-benzenedicarboxylate have synergistic effects against HIV infection
Abstract book·2006
Sulfasalazine transport in in-vitro, ex-vivo and in-vivo absorption models: contribution of efflux carriers and their modulation by co-administration of synthetic nature-identical fruit extracts
Journal of Pharmacy and Pharmacology·2005· 29 citedOpen Access
P-Glycoprotein Attenuating Effect of Human Intestinal Fluid
Pharmaceutical Research·2003· 36 cited
Screening of Tanzanian plant extracts for their potential inhibitory effect on P‐glycoprotein mediated efflux
Phytotherapy Research·2003· 15 cited
Implementation of the caco-2 cell culture model as a predictive tool for the oral absorption of drugs. In-house evaluation procedures.
PubMed·2003· 6 cited
The effect of food components on the absorption of P-gp substrates: a review
Journal of Pharmacy and Pharmacology·2003· 73 citedOpen Access
Apricot Extract Inhibits the P-gp–Mediated Efflux of Talinolol
Journal of Pharmaceutical Sciences·2002· 28 cited
Inhibitory effect of fruit extracts on P-glycoproteinrelated efflux carriers: an in-vitro screening
Journal of Pharmacy and Pharmacology·2002· 43 cited
Intestinal Absorption Enhancement of the Ester Prodrug Tenofovir Disoproxil Fumarate through Modulation of the Biochemical Barrier by Defined Ester Mixtures
Drug Metabolism and Disposition·2002· 93 cited
Intestinal absorption characteristics of the low solubility thiocarboxanilide UC-781
International Journal of Pharmaceutics·2002· 24 cited
Attenuation of P-gp modulation by human intestinal fluid: an in vitro study
2002
Modulation of P-gp mediated efflux of Cyclosporin A by human intestinal fluid in the Caco-2 system
2002
Simulated intestinal fluid as transport medium in the Caco-2 cell culture model
International Journal of Pharmaceutics·2002· 166 cited
Absorption enhancement by modulation of intestinal P-gp activity by apricot extract: an in situ study
2002
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Frequent Co-authors

Patrick Augustijns(38), J. Van Gelder(16), Guy Van den Mooter(15), Erik De Clercq(11), Renaat Kinget(10), Lieve Naesens(9), Renaat Kinget(7), Guy Van den Mooter(6), Pieter Annaert(6), F. Ingels(5), M. Oth(4), Jan Tack(4), Raf Mols(3), Jan Balzarini(3), Peter de Witte(3), Frank Lammert(2), Éric Destexhe(2), Joachim Brouwers(2), Nico Vermeulen(2), Raf Mols(2)