Donato Goffredo

Fondazione IRCCS Istituto Neurologico Carlo Besta — Italy

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index3.3kcitations16works0.02yr avg
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Research Topics

Mitochondrial Function and Pathology(7), Genetic Neurodegenerative Diseases(7), Pluripotent Stem Cells Research(4), Muscle Physiology and Disorders(3), Neurogenesis and neuroplasticity mechanisms(3)

Publications16 total

Neocortical Variation of Aβ Load in Fully Expressed, Pure Alzheimer's Disease
Journal of Alzheimer s Disease·2010· 22 cited
An optimized experimental strategy for efficient conversion of embryonic stem (ES)-derived mouse neural stem (NS) cells into a nearly homogeneous mature neuronal population
Neurobiology of Disease·2009· 64 citedOpen Access
p66ShcA adaptor molecule accelerates ES cell neural induction
Molecular and Cellular Neuroscience·2009· 9 cited
Setting the conditions for efficient, robust and reproducible generation of functionally active neurons from adult subventricular zone-derived neural stem cells
Cell Death and Differentiation·2008· 30 citedOpen Access
Differentiating embryonic stem–derived neural stem cells show a maturation-dependent pattern of voltage-gated sodium current expression and graded action potentials
Neuroscience·2007· 42 cited
Adherent Neural Stem (NS) Cells from Fetal and Adult Forebrain
Cerebral Cortex·2006· 261 citedOpen Access
Dysfunction of the Cholesterol Biosynthetic Pathway in Huntington's Disease
Journal of Neuroscience·2005· 281 citedOpen Access
From target identification to drug screening assays for neurodegenerative diseases
Pharmacological Research·2005· 8 cited
Prevention of cytosolic IAPs degradation: a potential pharmacological target in Huntington's Disease
Pharmacological Research·2005· 46 cited
Impaired cholesterol biosynthesis in huntingtons's disease models
2005
Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes
Nature Genetics·2003· 926 cited
Calcium-dependent Cleavage of Endogenous Wild-type Huntingtin in Primary Cortical Neurons
Journal of Biological Chemistry·2002· 84 citedOpen Access
Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease
Science·2001· 1.3k cited
Huntingtin's Neuroprotective Activity Occurs via Inhibition of Procaspase-9 Processing
Journal of Biological Chemistry·2001· 163 citedOpen Access
Topographic distribution of PRPRES in Creutzfeldt-Jakob disease as revealed by immunohistochemistry
Neurobiology of Aging·2000
Creutzfeldt‐Jakob Disease: Carnoy's Fixative Improves the Immunohistochemistry of the Proteinase K‐ Resistant Prion Protein
Brain Pathology·2000· 55 citedOpen Access

Frequent Co-authors

Elena Cattaneo(12), Chiara Zuccato(8), Dorotea Rigamonti(7), Luciano Conti(7), Marzia Tartari(6), Simonetta Sipione(4), Marta Valenza(4), Francesca Di Febo(3), Gerardo Biella(3), Mauro Toselli(3), Giorgio Giaccone(3), Fabrizio Tagliavini(3), Orso Bugiani(3), Alessia Moiana(3), Blair R. Leavitt(2), Michael R. Hayden(2), Tõnis Timmusk(2), Simone Fenu(2), Laure Jamot(2), Ben Woodman(2)