Mark Frasier

Michael J. Fox Foundation — United States

Medicine · Health Sciences

32h-index7.7kcitations83works56.82yr avg
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Research Topics

Parkinson's Disease Mechanisms and Treatments(69), Neurological disorders and treatments(31), Nuclear Receptors and Signaling(18), Autism Spectrum Disorder Research(10), Alzheimer's disease research and treatments(9)

Publications80 total

Dermal Phospho-Alpha-Synuclein Among Individuals With and Without Cerebrospinal Fluid Aggregated Alpha-Synuclein
2025Open Access
Expression of human A53T alpha-synuclein without endogenous rat alpha-synuclein fails to elicit Parkinson’s disease-related phenotypes in a novel humanized rat model
PLoS ONE·2025Open Access
The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging
Nature Medicine·2025· 48 citedOpen Access
Cognitive Performance in Early Neuronal Synuclein Disease with Hyposmia but without Motor Disability: Association with Dopamine Deficiency and Isolated Rapid Eye Movement Sleep Behavior Disorder
Annals of Neurology·2025· 1 citedOpen Access
<i>LRRK2</i> -associated parkinsonism with and without <i>in vivo</i> evidence of alpha-synuclein aggregates: longitudinal clinical and biomarker characterization
Brain Communications·2025· 8 citedOpen Access
Impact of dopamine deficiency and REM sleep behavior disorder on cognition in early neuronal synuclein disease with hyposmia
2024Open Access
Neuronal alpha-Synuclein Disease integrated staging system performance in PPMI, PASADENA, and SPARK baseline cohorts
npj Parkinson s Disease·2024· 25 citedOpen Access
Long-Term Dementia Risk in Parkinson Disease
Neurology·2024· 55 citedOpen Access
Biological Staging of the Parkinson’s Progression Markers Initiative (PPMI) Cohort Using the Research Neuronal α-synuclein Disease Integrated Staging System (NSD-ISS) (P11-3.009)
Neurology·2024Open Access
Neuronal alpha-Synuclein Disease Integrated Staging System performance in PPMI, PASADENA, and SPARK baseline cohorts
2024· 4 citedOpen Access
A biological definition of neuronal α-synuclein disease: towards an integrated staging system for research
The Lancet Neurology·2024· 484 citedOpen Access
A Biological Definition and Integrated Staging System of Neuronal alpha-Synuclein Disease
Zenodo (CERN European Organization for Nuclear Research)·2023· 2 citedOpen Access
Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using α-synuclein seed amplification: a cross-sectional study
The Lancet Neurology·2023· 620 citedOpen Access
Assessment of heterogeneity and disease onset in the Parkinson’s Progression Markers Initiative (PPMI) cohort using the α-synuclein seed amplification assay: a cross-sectional study
2023· 3 citedOpen Access
A proteogenomic view of Parkinson’s disease causality and heterogeneity
npj Parkinson s Disease·2023· 51 citedOpen Access
High Diagnostic Accuracy of the Α-Synuclein Seed Amplification Assay Informs Parkinson's Disease Heterogeneity and Disease Onset in the PPMI Cohort
SSRN Electronic Journal·2023Open Access
Precision medicine for Parkinson’s disease: The subtyping challenge
Frontiers in Aging Neuroscience·2022· 17 citedOpen Access
Longitudinal clinical and biomarker characteristics of non-manifesting LRRK2 G2019S carriers in the PPMI cohort
npj Parkinson s Disease·2022· 18 citedOpen Access
Deep Learning for Daily Monitoring of Parkinson’s Disease Outside the Clinic Using Wearable Sensors
Sensors·2022· 25 citedOpen Access
Evaluation of the PREDIGT score’s performance in identifying newly diagnosed Parkinson’s patients without motor examination
npj Parkinson s Disease·2022· 4 citedOpen Access
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Frequent Co-authors

Brit Mollenhauer(23), Todd Sherer(22), Kenneth Marek(21), Andrew Singleton(18), Andrew Siderowf(17), Lana M. Chahine(17), Caroline M. Tanner(16), Tanya Simuni(15), Douglas Galasko(14), Christopher S. Coffey(14), Tatiana Foroud(14), Sohini Chowdhury(13), John Seibyl(13), Chelsea Caspell‐Garcia(13), Daniel Weintraub(13), Kathleen L. Poston(11), Kalpana Merchant(11), Karl Kieburtz(10), Danna Jennings(9), Penelope Hogarth(9)