Samuel J.I. Blackford

Imperial College London — United Kingdom

Medicine · Health Sciences

14h-index1.5kcitations22works1.02yr avg
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Research Topics

Liver physiology and pathology(9), Pluripotent Stem Cells Research(6), Retinal Development and Disorders(6), Photoreceptor and optogenetics research(4), CRISPR and Genetic Engineering(3)

Publications22 total

Reduction of Z alpha-1 antitrypsin polymers in human iPSC-hepatocytes and mice by LRRK2 inhibitors
Hepatology·2024· 1 cited
RGD density along with substrate stiffness regulate hPSC hepatocyte functionality through YAP signalling
Biomaterials·2022· 26 citedOpen Access
Dysregulated RNA polyadenylation contributes to metabolic impairment in non-alcoholic fatty liver disease
Nucleic Acids Research·2022· 28 citedOpen Access
Sulfated Alginate Reduces Pericapsular Fibrotic Overgrowth on Encapsulated cGMP-Compliant hPSC-Hepatocytes in Mice
Frontiers in Bioengineering and Biotechnology·2022· 16 citedOpen Access
Small molecule screen employing patient-derived iPSC hepatocytes identifies LRRK2 as a novel therapeutic target for Alpha1 Antitrypsin Deficiency
2022Open Access
Human iPSC-derived hepatocyte system models cholestasis with tight junction protein 2 deficiency
JHEP Reports·2022· 13 citedOpen Access
Small molecule screen employing patient-derived iPS hepatocytes identifies LRRK2 as a novel therapeutic target for Alpha1 Antitrypsin Deficiency
2021Open Access
Reporter gene-engineering of human induced pluripotent stem cells during differentiation renders in vivo traceable hepatocyte-like cells accessible
Stem Cell Research·2019· 15 citedOpen Access
Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors
Nature Communications·2019· 129 citedOpen Access
Issue Information
Stem Cells Translational Medicine·2019Open Access
Validation of Current Good Manufacturing Practice Compliant Human Pluripotent Stem Cell-Derived Hepatocytes for Cell-Based Therapy
Stem Cells Translational Medicine·2018· 65 citedOpen Access
Human iPS derived progenitors bioengineered into liver organoids using an inverted colloidal crystal poly (ethylene glycol) scaffold
Biomaterials·2018· 130 citedOpen Access
Validation of a library of cGMP-compliant human pluripotent stem cell lines for use in liver therapy
2018· 1 citedOpen Access
Conversion of iPS derived hepatic progenitors into scalable, functional and developmentally relevant human organoids using an inverted colloidal crystal poly (ethylene glycol) scaffold engineered from collagen-coated pores of defined size
2018Open Access
Single-cell analysis identifies EpCAM <sup>+</sup> /CDH6 <sup>+</sup> /TROP-2 <sup>−</sup> cells as human liver progenitors
2018· 2 citedOpen Access
Assessment of AAV Vector Tropisms for Mouse and Human Pluripotent Stem Cell–Derived RPE and Photoreceptor Cells
Human Gene Therapy·2018· 66 cited
Transplanted Donor- or Stem Cell-Derived Cone Photoreceptors Can Both Integrate and Undergo Material Transfer in an Environment-Dependent Manner
Stem Cell Reports·2018· 130 citedOpen Access
Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors
Stem Cell Reports·2017· 236 citedOpen Access
Differentiation and Transplantation of Embryonic Stem Cell-Derived Cone Photoreceptors into a Mouse Model of End-Stage Retinal Degeneration
Stem Cell Reports·2017· 100 citedOpen Access
Transplantation of Photoreceptor Precursors Isolated via a Cell Surface Biomarker Panel from Embryonic Stem Cell-Derived Self-Forming Retina
Stem Cells·2015· 116 citedOpen Access
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Frequent Co-authors

S. Tamir Rashid(13), Joe M. Segal(10), Soon Seng Ng(9), Deniz Kent(7), Anai Gonzalez-Cordero(6), R. A. Pearson(6), Robin R. Ali(6), Adam Syanda(6), Emma L. West(5), Arifa Naeem(5), Alexander J. Smith(5), Jane C. Sowden(5), Yanaí Durán(4), James Bainbridge(4), Kamil Kruczek(4), Magdalena Kloc(4), Debbie Goh(4), Robert D. Sampson(4), Maria Paola Serra(4), Hiromitsu Nakauchi(4)