Matthias R. Bauer

Novartis (Switzerland) — Switzerland

Medicine · Health Sciences

23h-index2.1kcitations61works4.82yr avg
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Research Topics

Cancer-related Molecular Pathways(15), Computational Drug Discovery Methods(13), Machine Learning in Materials Science(10), Protein Structure and Dynamics(9), Click Chemistry and Applications(7)

Publications61 total

Harnessing Glutamine-117 Plasticity toward Structure-Based Identification of Triazole IL-17 Inhibitors
Journal of Medicinal Chemistry·2025
Discovery of Small-Molecule Ligands for the E3 Ligase STUB1/CHIP from a DNA-Encoded Library Screen
ACS Medicinal Chemistry Letters·2025· 1 citedOpen Access
Thiazole‐Based IL‐17 Inhibitors Discovered by Scaffold Morphing
ChemMedChem·2024· 7 citedOpen Access
Discovery and <i>In Vivo</i> Exploration of 1,3,4-Oxadiazole and α-Fluoroacrylate Containing IL-17 Inhibitors
Journal of Medicinal Chemistry·2024· 6 cited
mRNA Display Identifies Potent, Paralog-Selective Peptidic Ligands for ARID1B
ACS Chemical Biology·2024· 2 citedOpen Access
Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders
Journal of Medicinal Chemistry·2024· 13 cited
Design and Evaluation of a Low Hydrogen Bond Donor Count Fragment Screening Set to Aid Hit Generation of PROTACs Intended for Oral Delivery
Journal of Medicinal Chemistry·2023· 12 cited
Icolos: a workflow manager for structure-based post-processing of <i>de novo</i> generated small molecules
Bioinformatics·2022· 13 citedOpen Access
Icolos: A workflow manager for structure based post-processing of de novo generated small molecules
2022· 4 citedOpen Access
Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and SARS-CoV-2 variants
2021· 9 citedOpen Access
DockStream: a docking wrapper to enhance de novo molecular design
Journal of Cheminformatics·2021· 73 citedOpen Access
DockStream: A Docking Wrapper to Enhance De Novo Molecular Design
2021· 9 citedOpen Access
DockStream: A Docking Wrapper to Enhance De Novo Molecular Design
2021· 10 citedOpen Access
Additional file 1 of DockStream: a docking wrapper to enhance de novo molecular design
Figshare·2021Open Access
Put a ring on it: application of small aliphatic rings in medicinal chemistry
RSC Medicinal Chemistry·2021· 419 citedOpen Access
Supporting SARS-CoV-2 Papain-Like Protease Drug Discovery: In silico Methods and Benchmarking
Frontiers in Chemistry·2020· 40 citedOpen Access
Cytoplasmic expression of High mobility group A2 (HMGA2) determines survival prognoses in breast cancer patients
Geburtshilfe und Frauenheilkunde·2020
Cytoplasmic expression of High mobility group A2 (HMGA2) determines survival prognoses in breast cancer patients
Senologie - Zeitschrift für Mammadiagnostik und -therapie·2020
Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm
ACS Chemical Biology·2020· 76 citedOpen Access
A Structure-Guided Molecular Chaperone Approach for Restoring the Transcriptional Activity of the p53 Cancer Mutant Y220C
Future Medicinal Chemistry·2019· 81 citedOpen Access
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Frequent Co-authors

Frank M. Boeckler(16), Alan R. Fersht(13), Andreas C. Joerger(9), Christian Margreitter(7), Tamer M. Ibrahim(6), Rainer Wilcken(6), Atanas Patronov(6), Ola Engkvist(6), Jeff Guo(5), Simon Vogel(4), Matthias G. J. Baud(4), John Spencer(4), Jon Paul Janet(4), Eva Nittinger(4), Kathryn A. Giblin(4), Kostas Papadopoulos(4), Alexey Voronov(4), Simon C. C. Lucas(3), Richard Storer(3), Rhiannon N. Jones(3)