Jon Iker Etchegaray

Gladstone Institutes — United States

Immunology and Microbiology · Life Sciences

12h-index767citations20works8.62yr avg
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Research Topics

Phagocytosis and Immune Regulation(11), Neuroinflammation and Neurodegeneration Mechanisms(5), Immune cells in cancer(4), Alzheimer's disease research and treatments(3), Retinal Diseases and Treatments(2)

Publications20 total

Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD
Communications Biology·2025· 1 citedOpen Access
Early life high fructose impairs microglial phagocytosis and neurodevelopment
Nature·2025· 12 citedOpen Access
WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity
Nature Communications·2025Open Access
Role of RPE Phagocytosis in the Retina Metabolic Ecosystem
Advances in experimental medicine and biology·2025· 3 cited
Rapid unleashing of macrophage efferocytic capacity via transcriptional pause release
Nature·2024· 27 citedOpen Access
Early life high fructose exposure disrupts microglia function and impedes neurodevelopment
2023· 6 citedOpen Access
Phagocytosis in the retina promotes local insulin production in the eye
Nature Metabolism·2023· 25 citedOpen Access
Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments
Cell Metabolism·2022· 76 citedOpen Access
Novel adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments
2022Open Access
Pannexin 1 drives efficient epithelial repair after tissue injury
Science Immunology·2022· 42 citedOpen Access
Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia
Scientific Reports·2020· 18 citedOpen Access
Microglial microRNAs mediate sex-specific responses to tau pathology
Nature Neuroscience·2019· 107 citedOpen Access
Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway
Nature Cell Biology·2019· 101 citedOpen Access
The Role of Progranulin in Retinal Homeostasis and Degeneration in the Context of Lysosomal Storage Disease
Investigative Ophthalmology & Visual Science·2019Open Access
P4‐511: A NOVEL ROLE FOR THE FTD‐CAUSING PROTEIN PROGRANULIN IN APOPTOSIS SIGNALING
Alzheimer s & Dementia·2019Open Access
Microglial NFκB-TNFα hyperactivation induces obsessive–compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia
Proceedings of the National Academy of Sciences·2017· 131 citedOpen Access
Defective Phagocytic Corpse Processing Results in Neurodegeneration and Can Be Rescued by TORC1 Activation
Journal of Neuroscience·2016· 59 citedOpen Access
Phagocytosis genes nonautonomously promote developmental cell death in the <i>Drosophila</i> ovary
Proceedings of the National Academy of Sciences·2016· 68 citedOpen Access
Draper acts through the JNK pathway to control synchronous engulfment of dying germline cells by follicular epithelial cells
Journal of Cell Science·2012· 1 cited
Draper acts through the JNK pathway to control synchronous engulfment of dying germline cells by follicular epithelial cells
Development·2012· 90 citedOpen Access

Frequent Co-authors

Christopher D. Lucas(8), Li Gan(7), Justin S. A. Perry(7), David Le(5), Faten A. Sayed(5), Kodi S. Ravichandran(5), Alissa Trzeciak(5), Waleska Saitz Rojas(5), Pedro Saavedra(5), Lihong Zhan(4), Christopher N. Parkhurst(4), Yaqiao Li(4), Yungui Zhou(4), Michael H. Raymond(4), Kimberly McCall(4), Kayvan R. Keshari(4), Lay Kodama(3), Claire D. Clelland(3), Brady Barron(3), Allison K. Timmons(3)