Bahige M. Baroudy

Medicine · Health Sciences

42h-index5.9kcitations76works0.02yr avg
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Research Topics

Hepatitis C virus research(31), HIV Research and Treatment(25), Hepatitis B Virus Studies(19), HIV/AIDS drug development and treatment(18), Immune Cell Function and Interaction(15)

Publications76 total

Sequence analysis of hepatitis A vi: proteins and RNA polymerase
2016
ChemInform Abstract: Sch 213766, a Novel Chemokine Receptor CCR‐5 Inhibitor from Chaetomium globosum.
ChemInform·2008
Sch 213766, A Novel Chemokine Receptor CCR-5 Inhibitor from Chaetomium globosum
The Journal of Antibiotics·2007· 30 citedOpen Access
In vitro antiviral activity of SCH446211 (SCH6), a novel inhibitor of the hepatitis C virus NS3 serine protease
Journal of Antimicrobial Chemotherapy·2006· 18 citedOpen Access
Discovery of (1 <i>R</i> ,5 <i>S</i> )- <i>N</i> -[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2( <i>S</i> )-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2( <i>S</i> )-carboxamide (SCH 503034), a Selective, Potent, Orally Bioavailable Hepatitis C Virus NS3 Protease Inhibitor:  A Potential Therapeutic Agent for the Treatment of Hepatitis C Infection
Journal of Medicinal Chemistry·2006· 278 citedOpen Access
Chemokine Receptor CCR-5 Inhibitors Produced by<i>Chaetomium</i><i>g</i><i>lobosum</i>
Journal of Natural Products·2006· 57 citedOpen Access
Discovery of SCH446211 (SCH6):  A New Ketoamide Inhibitor of the HCV NS3 Serine Protease and HCV Subgenomic RNA Replication
Journal of Medicinal Chemistry·2006· 59 citedOpen Access
Interaction of small molecule inhibitors of HIV-1 entry with CCR5
Virology·2006· 121 cited
Depeptidization efforts on <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si2.gif" overflow="scroll"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">P</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub><mml:ms>–</mml:ms><mml:msubsup><mml:mrow><mml:mi mathvariant="normal">P</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow><mml:mrow><mml:mo>′</mml:mo></mml:mrow></mml:msubsup></mml:mrow></mml:math> α-ketoamide inhibitors of HCV NS3-4A serine protease: Effect on HCV replicon activity
Bioorganic & Medicinal Chemistry Letters·2006· 18 citedOpen Access
Antiviral Activity of Transiently Expressed IFN-κ Is Cell-Associated
Journal of Interferon & Cytokine Research·2006· 22 cited
HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with P1 and P2 cyclopropylalannines
2005
Discovery and Characterization of Vicriviroc (SCH 417690), a CCR5 Antagonist with Potent Activity against Human Immunodeficiency Virus Type 1
Antimicrobial Agents and Chemotherapy·2005· 214 citedOpen Access
Generation and properties of a human immunodeficiency virus type 1 isolate resistant to the small molecule CCR5 inhibitor, SCH-417690 (SCH-D)
Virology·2005· 152 cited
Genetic and Phenotypic Analyses of Human Immunodeficiency Virus Type 1 Escape from a Small-Molecule CCR5 Inhibitor
Journal of Virology·2004· 3 citedOpen Access
Piperazine-Based CCR5 Antagonists as HIV-1 Inhibitors. IV. Discovery of 1-[(4,6-Dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-{2-methoxy-1(<i>R</i>)-4-(trifluoromethyl)phenyl}ethyl-3(<i>S</i>)-methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a Potent, Highly Selective, and Orally Bioavailable CCR5 Antagonist
Journal of Medicinal Chemistry·2004· 136 citedOpen Access
The Differential Sensitivity of Human and Rhesus Macaque CCR5 to Small-Molecule Inhibitors of Human Immunodeficiency Virus Type 1 Entry Is Explained by a Single Amino Acid Difference and Suggests a Mechanism of Action for These Inhibitors
Journal of Virology·2004· 42 citedOpen Access
Genetic and Phenotypic Analyses of Human Immunodeficiency Virus Type 1 Escape from a Small-Molecule CCR5 Inhibitor
Journal of Virology·2004· 196 citedOpen Access
Oximino‐Piperidino‐Piperidine‐Based CCR5 Antagonists. Part 2. Synthesis, SAR and Biological Evaluation of Symmetrical Heteroaryl Carboxamides.
ChemInform·2003
Expression of a Novel Murine Type I IFN in the Pancreatic Islets Induces Diabetes in Mice
The Journal of Immunology·2003· 38 citedOpen Access
The effect of ribavirin and IMPDH inhibitors on hepatitis C virus subgenomic replicon RNA
Virology·2003· 176 cited
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Frequent Co-authors

Julie Strizki(13), Jayaram R. Tagat(9), Stuart W. McCombie(9), Kathleen Cox(9), Robert H. Purcell(8), Anandan Palani(8), John W. Clader(8), John P. Moore(8), Gregory R. Reyes(7), Shawn E. Kuhmann(6), Serena Xu(6), Sherry Shapiro(6), Nicole Wagner(5), William J. Greenlee(5), Bernard Moss(5), John R. Ticehurst(4), Alexandra Trkola(4), Lisa Wojcik(4), M. Endres(4), Ruo W. Steensma(4)