Serena Xu

James J. Peters VA Medical Center — United States

Immunology and Microbiology · Life Sciences

15h-index2.9kcitations24works9.02yr avg
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Research Topics

HIV Research and Treatment(14), Immune Cell Function and Interaction(8), HIV/AIDS drug development and treatment(7), Medical Imaging Techniques and Applications(4), T-cell and B-cell Immunology(3)

Publications24 total

Combinatorial macrophage induced innate immunotherapy against Ewing sarcoma: Turning “Two Keys” simultaneously
Journal of Experimental & Clinical Cancer Research·2024· 9 citedOpen Access
An orally available non-nucleotide STING agonist with antitumor activity
Science·2020· 611 cited
Live Cell Membranome cDNA Screen: A Novel Homogenous Live Cell Binding Assay to Study Membrane Protein-Ligand Interaction
SLAS DISCOVERY·2019· 2 citedOpen Access
Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING
ACS Medicinal Chemistry Letters·2018· 163 citedOpen Access
Synthesis and preliminary PET imaging studies of [18F]MK-6240: A radiotracer for imaging neurofibrillary tangles (NFTs) in Alzheimer's disease
2016
IC‐P‐187: Discovery and First‐in‐Human Evaluation of the TAU‐imaging PET Radiotracer [<sup>18</sup>F]MK‐6240
Alzheimer s & Dementia·2016· 1 cited
P1‐246: Discovery and First‐in‐Human Evaluation of the TAU‐Imaging PET Radiotracer [<sup>18</sup>F]MK‐6240
Alzheimer s & Dementia·2016
Preclinical Characterization of<sup>18</sup>F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles
Journal of Nuclear Medicine·2016· 278 citedOpen Access
Discovery of 6-(Fluoro-<sup>18</sup><i>F</i>)-3-(1<i>H</i>-pyrrolo[2,3-<i>c</i>]pyridin-1-yl)isoquinolin-5-amine ([<sup>18</sup>F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)
Journal of Medicinal Chemistry·2016· 175 cited
Applying Dataflow Architecture and Visualization Tools to In Vitro Pharmacology Data Automation
SLAS TECHNOLOGY·2016· 5 citedOpen Access
Optimization of Interruptions in HIV treatment using a multiscale mechanistic model
2014
Discovery and Characterization of Vicriviroc (SCH 417690), a CCR5 Antagonist with Potent Activity against Human Immunodeficiency Virus Type 1
Antimicrobial Agents and Chemotherapy·2005· 214 citedOpen Access
Generation and properties of a human immunodeficiency virus type 1 isolate resistant to the small molecule CCR5 inhibitor, SCH-417690 (SCH-D)
Virology·2005· 152 cited
HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use
Proceedings of the National Academy of Sciences·2002· 303 citedOpen Access
ChemInform Abstract: Piperazine‐Based CCR5 Antagonists as HIV‐1 Inhibitors. Part 1. 2(S)‐Methyl Piperazine as a Key Pharmacophore Element.
ChemInform·2001
SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection<i>in vitro</i>and<i>in vivo</i>
Proceedings of the National Academy of Sciences·2001· 300 citedOpen Access
Piperazine-Based CCR5 Antagonists as HIV-1 Inhibitors. II. Discovery of 1-[(2,4-Dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(<i>S</i>)-methyl-4-[1(<i>S</i>)-[4-(trifluoro- methyl)phenyl]ethyl]-1-piperazinyl]- piperidine <i>N</i>1-Oxide (Sch-350634), an Orally Bioavailable, Potent CCR5 Antagonist
Journal of Medicinal Chemistry·2001· 112 citedOpen Access
Piperazine-Based CCR5 antagonists as HIV-1 inhibitors. I: 2(S)-methyl piperazine as a key pharmacophore element
Bioorganic & Medicinal Chemistry Letters·2001· 65 citedOpen Access
Neutralization of Syncytium‐Inducing Primary Isolates by Sera from Human Immunodeficiency Virus (HIV)–Uninfected Recipients of Candidate HIV Vaccines
The Journal of Infectious Diseases·1998· 16 cited
Neutralization Profiles of Primary Human Immunodeficiency Virus Type 1 Isolates in the Context of Coreceptor Usage
Journal of Virology·1998· 215 citedOpen Access
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Frequent Co-authors

Bahige M. Baroudy(7), Jayaram R. Tagat(6), Susan Zolla‐Pazner(6), Julie Strizki(5), Stuart W. McCombie(5), Zhizhen Zeng(5), Idriss Bennacef(5), Cristian Salinas(5), Brett Connolly(5), Liza Gantert(5), Mona Purcell(5), Kerry Riffel(5), Talakad G. Lohith(5), Paul J. Coleman(5), Aileen Soriano(5), Aimie M. Ogawa(5), David Hesk(5), Jeffrey L. Evelhoch(5), Sherri Burda(5), Lisa Wojcik(4)