Aileen Soriano

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Medicine · Health Sciences

18h-index1.5kcitations46works1.02yr avg
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Research Topics

Hepatitis C virus research(6), Computational Drug Discovery Methods(6), Biochemical and Molecular Research(5), Nitric Oxide and Endothelin Effects(4), Medical Imaging Techniques and Applications(4)

Publications46 total

WRN structural flexibility showcased through fragment-based lead discovery of inhibitors
Nature Communications·2026Open Access
WRN structural flexibility showcased through fragment-based lead discovery of inhibitors
Figshare·2026Open Access
WRN structural flexibility showcased through fragment-based lead discovery of inhibitors
Figshare·2026Open Access
WRN helicase structural flexibility showcased through fragment-based lead discovery of inhibitors
Structural Dynamics·2025Open Access
Antibacterial macrocyclic peptides reveal a distinct mode of BamA inhibition
Nature Communications·2025· 6 citedOpen Access
Structural insights into selective small molecule activation of PKG1α
2024Open Access
Structural insights into selective small molecule activation of PKG1α
Communications Biology·2023· 3 citedOpen Access
Exploring The Level of Student Teaching Performance of The Pre-Service Teachers
Journal for Educators Teachers and Trainers·2023Open Access
Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1α
Journal of Medicinal Chemistry·2022· 3 citedOpen Access
Mechanistic insights on novel small molecule allosteric activators of cGMP-dependent protein kinase PKG1α
Journal of Biological Chemistry·2022· 5 citedOpen Access
Discovery of the First Non-cGMP Mimetic Small Molecule Activators of cGMP-Dependent Protein Kinase 1 α (PKG1α)
ACS Medicinal Chemistry Letters·2021· 5 citedOpen Access
Affinity Selection–Mass Spectrometry Identifies a Novel Antibacterial RNA Polymerase Inhibitor
ACS Chemical Biology·2017· 17 citedOpen Access
Design and Synthesis of P2–P4 Macrocycles Containing a Unique Spirocyclic Proline: A New Class of HCV NS3/4A Inhibitors
ACS Medicinal Chemistry Letters·2016· 27 citedOpen Access
Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors
Bioorganic & Medicinal Chemistry·2016· 17 citedOpen Access
Synthesis and preliminary PET imaging studies of [18F]MK-6240: A radiotracer for imaging neurofibrillary tangles (NFTs) in Alzheimer's disease
2016
IC‐P‐199: Comparing [<sup>3</sup>H]MK‐6240 and [<sup>3</sup>H]AV‐1451(T‐807) In <i>In vitro</i> Binding Studies in Brain Tissues
Alzheimer s & Dementia·2016
IC‐P‐187: Discovery and First‐in‐Human Evaluation of the TAU‐imaging PET Radiotracer [<sup>18</sup>F]MK‐6240
Alzheimer s & Dementia·2016· 1 cited
P1‐246: Discovery and First‐in‐Human Evaluation of the TAU‐Imaging PET Radiotracer [<sup>18</sup>F]MK‐6240
Alzheimer s & Dementia·2016
P1‐244: Comparing [<sup>3</sup>H]MK‐6240 and [<sup>3</sup>H]AV‐1451(T‐807) in <i>in VITRO</i> Binding Studies in Brain Tissues
Alzheimer s & Dementia·2016Open Access
Preclinical Characterization of<sup>18</sup>F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles
Journal of Nuclear Medicine·2016· 278 citedOpen Access
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Frequent Co-authors

Paul J. Coleman(9), Zhizhen Zeng(7), Idriss Bennacef(7), Brett Connolly(7), David Hesk(7), Abbas Walji(6), Stacey O’Malley(6), J. A. Cowan(6), Eric D. Hostetler(5), Patricia Miller(5), Cristian Salinas(5), Liza Gantert(5), Mona Purcell(5), Kerry Riffel(5), Talakad G. Lohith(5), Aimie M. Ogawa(5), Serena Xu(5), Jeffrey L. Evelhoch(5), Jennifer Hanisak(5), Marie A. Holahan(4)