Peter Harley

Wellcome Centre for Cell-Matrix Research — United Kingdom

Neuroscience · Life Sciences

11h-index494citations25works6.42yr avg
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Research Topics

Neuroscience and Neural Engineering(5), CRISPR and Genetic Engineering(4), Neurobiology and Insect Physiology Research(3), Muscle Physiology and Disorders(3), Nerve injury and regeneration(3)

Publications25 total

Human pluripotent stem cell model of multiple epiphyseal dysplasia with MATN3 mutation identifies altered matrix organisation and upregulation of the cholesterol biosynthesis pathway
Osteoarthritis and Cartilage·2026Open Access
U7 small nuclear RNA splice-switching therapeutics for STMN2 and UNC13A in Amyotrophic Lateral Sclerosis
2025Open Access
TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD
Nature Neuroscience·2025· 5 citedOpen Access
Human pluripotent stem cell model of multiple epiphyseal dysplasia with <i>MATN3</i> mutation identifies altered Matrix organisation and upregulation of the cholesterol biosynthesis pathway
2025Open Access
Creation of de novo cryptic splicing for ALS and FTD precision medicine
Science·2024· 27 citedOpen Access
Aberrant axon initial segment plasticity and intrinsic excitability of ALS hiPSC motor neurons
Cell Reports·2023· 31 citedOpen Access
Creation of de novo cryptic splicing for ALS/FTD precision medicine
2023· 5 citedOpen Access
A scalable human iPSC-based neuromuscular disease model on suspended biobased elastomer nanofiber scaffolds
Biofabrication·2023· 14 citedOpen Access
Modelling renal defects in Bardet-Biedl syndrome patients using human iPS cells
Frontiers in Cell and Developmental Biology·2023· 3 citedOpen Access
<i>UNC13A</i>in amyotrophic lateral sclerosis: from genetic association to therapeutic target
Journal of Neurology Neurosurgery & Psychiatry·2023· 52 citedOpen Access
3D Compartmentalised Human Pluripotent Stem Cell–derived Neuromuscular Co-cultures
BIO-PROTOCOL·2023· 10 citedOpen Access
Pathogenic TDP-43 Disrupts Axon Initial Segment Structure and Neuronal Excitability in a Human iPSC Model of ALS
2022· 4 citedOpen Access
Biobased Elastomer Nanofibers Guide Light‐Controlled Human‐iPSC‐Derived Skeletal Myofibers
Advanced Materials·2022· 48 citedOpen Access
Optogenetic modeling of human neuromuscular circuits in Duchenne muscular dystrophy with CRISPR and pharmacological corrections
Science Advances·2021· 18 citedOpen Access
A transcriptional toolbox for exploring peripheral neuroimmune interactions
Pain·2020· 50 cited
Changes in the transcriptional fingerprint of satellite glial cells following peripheral nerve injury
Glia·2020· 109 cited
A transcriptional toolbox for exploring peripheral neuro-immune interactions
2019· 11 citedOpen Access
In Vitro Modeling of Nerve–Muscle Connectivity in a Compartmentalized Tissue Culture Device
Advanced Biosystems·2019· 50 citedOpen Access
Using Patient Derived Induced Pluripotent Stem Cells to Model Multiple Epiphyseal Dysplasia
57th Annual ESPE·2018
Bench to bedside: Current advances in regenerative medicine
Current Opinion in Cell Biology·2018· 18 cited
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Frequent Co-authors

Ivo Lieberam(8), Juan Burrone(5), Carolina Barcellos Machado(4), Aimee Cheesbrough(4), Federica Riccio(4), Puja R. Mehta(4), Matthew J. Keuss(4), Matteo Zanovello(4), Pietro Fratta(4), Sara E. Jager(3), Zoe Hore(3), Franziska Denk(3), Lea R’Bibo(3), Simone Barattucci(3), Nicola Bates(3), Geert Mortier(3), Virgile Viasnoff(2), Zhi Liang(2), Federico Uchenna Stanley(2), Aleksandra Michrowska(2)