Simone Barattucci

Queen Mary University of London — United Kingdom

Medicine · Health Sciences

5h-index106citations10works11.92yr avg
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Research Topics

Amyotrophic Lateral Sclerosis Research(6), RNA Research and Splicing(5), Neurogenetic and Muscular Disorders Research(5), T-cell and B-cell Immunology(1), Alzheimer's disease research and treatments(1)

Publications10 total

U7 small nuclear RNA splice-switching therapeutics for STMN2 and UNC13A in Amyotrophic Lateral Sclerosis
2025Open Access
TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD
Nature Neuroscience·2025· 5 citedOpen Access
TDP-43 loss induces cryptic polyadenylation in ALS/FTD
Nature Neuroscience·2025· 10 citedOpen Access
TDP-43 pathology induces CD8 <sup>+</sup> T cell activation through cryptic epitope recognition
2025· 2 citedOpen Access
Creation of de novo cryptic splicing for ALS and FTD precision medicine
Science·2024· 27 citedOpen Access
Axon guidance genes are regulated by <scp>TDP</scp> ‐43 and <scp>RGNEF</scp> through long‐intron removal
The FASEB Journal·2024· 2 citedOpen Access
Loss of TDP-43 induces synaptic dysfunction that is rescued by UNC13A splice-switching ASOs
2024· 25 citedOpen Access
TDP-43 loss induces extensive cryptic polyadenylation in ALS/FTD
2024· 23 citedOpen Access
Axon guidance genes are regulated by TDP-43 and RGNEF through the rate of long-intron processing
2023· 2 citedOpen Access
Unraveling the toxic effects mediated by the neurodegenerative disease–associated S375G mutation of TDP-43 and its S375E phosphomimetic variant
Journal of Biological Chemistry·2022· 9 citedOpen Access

Frequent Co-authors

Matteo Zanovello(7), Puja R. Mehta(6), Eugeni Ryadnov(5), Matthew J. Keuss(5), Francesca Mattedi(4), Pietro Fratta(4), Francesca Paron(4), Emanuele Buratti(4), Oscar G. Wilkins(3), Peter Harley(3), Anna‐Leigh Brown(3), Juan Burrone(3), Dario Dattilo(3), Sara Cappelli(3), Cristiana Stuani(3), Leonard Petrucelli(3), Max Z. Y. J. Chien(2), Elizabeth Fisher(2), Mala M. Shah(2), Sam Bryce-Smith(2)