Allan W. Nicholas

RTI International — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index1.7kcitations18works0.02yr avg
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Research Topics

Cancer therapeutics and mechanisms(12), Bioactive Compounds and Antitumor Agents(6), Microbial Natural Products and Biosynthesis(3), Cancer Treatment and Pharmacology(3), Phytochemicals and Medicinal Plants(3)

Publications18 total

ChemInform Abstract: Plant Antitumor Agents. Part 30. Synthesis and Structure Activity of Novel Camptothecin Analogs, e.g. (I).
ChemInform·1993
Synthesis of position‐specific tritium‐labeled 20(S)‐camptothecin, 9‐amino‐20(S)‐camptothecin, and 10,11‐methylenedioxy‐20(S)‐camptothecin
Journal of Labelled Compounds and Radiopharmaceuticals·1993· 5 cited
Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs
Journal of Medicinal Chemistry·1993· 138 citedOpen Access
Plant antitumor agents. 29. Synthesis and biological activity of ring D and ring E modified analogs of camptothecin
Journal of Medicinal Chemistry·1990· 72 cited
DNA Topoisomerase I—Targeted Chemotherapy of Human Colon Cancer in Xenografts
Science·1989· 645 cited
DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues.
PubMed·1989· 341 cited
Identity of Maprounic Acid with Aleuritolic Acid. Revision of the Structure of Maprounic Acid: X-ray Crystal Structure of p-Bromobenzyl Acetylmaprounate
Journal of Natural Products·1989· 11 cited
Plant antitumor agents. 28. Resolution of a key tricyclic synthon, 5'(RS)-1,5-dioxo-5'-hydroxy-2'H,5'H,6'H-6'-oxopyrano[3',4'-f].DELTA.6,8-tetrahydroindolizine: total synthesis and antitumor activity of 20(S)- and 20(R)-camptothecin
Journal of Medicinal Chemistry·1987· 111 cited
Plant antitumor agents. 25. Total synthesis and antileukemic activity of ring A substituted camptothecin analogs. Structure-activity correlations
Journal of Medicinal Chemistry·1987· 113 cited
ChemInform Abstract: Plant Antitumor Agents. Part 23. Synthesis and Antileukemic Activity of Camptothecin Analogues.
ChemInform·1987
ChemInform Abstract: Plant Antitumor Agents. Part 22. Isolation of 11‐Hydroxycamptothecin (I) from Camptotheca acuminata Decne: Total Synthesis and Biological Activity.
ChemInform·1987
Plant antitumor agents. 23. Synthesis and antileukemic activity of camptothecin analogs
Journal of Medicinal Chemistry·1986· 138 cited
Plant antitumor agents. 22. Isolation of 11-hydroxycamptothecin from Camptotheca acuminata decne: total synthesis and biological activity
Journal of Medicinal Chemistry·1986· 73 cited
Synthesis of mixed‐acid phosphatidylcholines and high pressure liquid chromatographic analysis of isomeric lysophosphatidylcholines
Lipids·1983· 28 cited
Microbial transformations of natural antitumor agents. 7. 14-alpha-hydroxylation of withaferin-a by cunninghamella elegans (NRRL 1393)
Steroids·1978· 22 cited
High-pressure liquid chromatography of derivatives and microbial metabolites of withaferin-A
Journal of Chromatography A·1977· 12 cited
Reactions of withaferin-A with model biological nucleophiles
Bioorganic Chemistry·1976· 9 cited
The stereochemistry of hydrogen addition by a Δ1-steroid reductase in baker's yeast
Biochemical and Biophysical Research Communications·1974· 3 cited

Frequent Co-authors

Monroe E. Wall(13), Mansukh C. Wani(6), Govindarajan Manikumar(5), Mansukh C. Wani(4), M. C. Wani(3), Leroy F. Liu(2), M Potmĕsil(2), Chhagan Tele(2), Linda B. Moore(2), Jeffrey M. Besterman(2), S. M. NATSCHKE(2), John P. N. Rosazza(2), Mark E. Gustafson(2), Beppino C. Giovanella(1), John S. Stehlin(1), Robert Silber(1), Y H Hsiang(1), S Kirschenbaum(1), R Silber(1), Anne T. Truesdale(1)