M. C. Wani

Triangle — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

15h-index5.1kcitations34works0.02yr avg
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Research Topics

Cancer therapeutics and mechanisms(15), Cancer Treatment and Pharmacology(8), Bioactive Compounds and Antitumor Agents(8), Microbial Natural Products and Biosynthesis(5), Plant chemical constituents analysis(3)

Publications34 total

Camptothecin Analogues with Bulky, Hydrophobic Substituents at the 7‐Position via a Grignard Reaction.
ChemInform·2005
Camptothecin analogs with bulky, hydrophobic substituents at the 7-position via a Grignard reaction
Bioorganic & Medicinal Chemistry Letters·2004· 14 citedOpen Access
Hydrophilic Camptothecin Analogs That Form Extremely Stable Cleavable Complexes with DNA and Topoisomerase I
Cancer Research·2004· 30 cited
Topoisomerase I-DNA Complex Stability Induced by Camptothecins and Its Role in Drug Activity&#
Current Medicinal Chemistry - Anti-Cancer Agents·2004· 17 cited
7- and 10-Substituted Camptothecins: Dependence of Topoisomerase I-DNA Cleavable Complex Formation and Stability on the 7- and 10-Substituents
Molecular Pharmacology·2000· 54 cited
Novel Strategies for the Discovery of Plant-Derived Anticancer Agents
1994· 12 cited
Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells.
PubMed·1991· 157 cited
DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues.
PubMed·1989· 341 cited
ChemInform Abstract: Plant Antitumor Agents. Part 23. Synthesis and Antileukemic Activity of Camptothecin Analogues.
ChemInform·1987
ChemInform Abstract: Plant Antitumor Agents. Part 22. Isolation of 11‐Hydroxycamptothecin (I) from Camptotheca acuminata Decne: Total Synthesis and Biological Activity.
ChemInform·1987
Development of General Antisera for Trichothecanes
1986
Esters and lactones of phenolic amino carboxylic acids. Prodrugs for iron chelation
Journal of Medicinal Chemistry·1986· 55 cited
Plant Antitumor Agents, 21. Flavones, Coumarins, and an Alkaloid from Sargentia greggii
Journal of Natural Products·1985· 23 cited
ChemInform Abstract: SYNTHESIS AND BIOLOGICAL ACTIVITY OF ZOAPATANOL ANALOGS
Chemischer Informationsdienst·1983
ChemInform Abstract: PLANT ANTITUMOR AGENTS. 18. SYNTHESIS AND BIOLOGICAL ACTIVITY OF CAMPTOTHECIN N ANALOGS
Chemischer Informationsdienst·1980· 1 cited
ChemInform Abstract: PLANT ANTITUMOR AGENTS. 17. STRUCTURAL REQUIREMENTS FOR ANTINEOPLASTIC ACTIVITY IN QUASSINOIDS
Chemischer Informationsdienst·1979
Plant antitumor agents. 17. Structural requirements for antineoplastic activity in quassinoids
Journal of Medicinal Chemistry·1978· 14 cited
ChemInform Abstract: SYNTHESIS AND CRYSTAL AND MOLECULAR STRUCTURE OF 17α‐ETHYNYL‐17β‐HYDROXY‐13β‐(3‐HYDROXYPROPYL)GON‐4‐EN‐3‐ONE
Chemischer Informationsdienst·1978
Antineoplastic Agents from Plants
The Annual Review of Pharmacology and Toxicology·1977· 94 cited
ChemInform Abstract: FLAVONOIDS. 8. SYNTHESIS AND ANTIFERTILITY AND ESTROGEN RECEPTOR BINDING ACTIVITIES OF COUMARINS AND Δ3‐ISOFLAVENES
Chemischer Informationsdienst·1976· 1 cited
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Frequent Co-authors

Monroe E. Wall(25), Govindarajan Manikumar(6), John A. Kepler(6), S. G. LEVINE(6), Daniel D. Von Hoff(5), Randy M. Wadkins(5), Allan W. Nicholas(3), James B. Thompson(3), H. F. Campbell(3), Samuel G. Levine(3), David J. Bearss(3), D. H. RECTOR(3), C. E. Cook(3), Andrew T. McPhail(2), Leroy F. Liu(2), M Potmĕsil(2), Colin G. Pitt(2), George A. Brine(2), J. N. McNaull(2), Harold L. Taylor(1)