Amy L. Stiegler

Yale University — United States

Materials Science · Physical Sciences

20h-index3.0kcitations57works1.02yr avg
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Research Topics

Enzyme Structure and Function(18), Protein Kinase Regulation and GTPase Signaling(16), Cellular transport and secretion(8), Glycosylation and Glycoproteins Research(5), Protein Structure and Dynamics(4)

Publications57 total

Two-Step Mechanism of Bruton’s Tyrosine Kinase Membrane Recruitment and Activation
2025Open Access
Nickel Binding to the c-Src SH3 Domain Facilitates Crystallization
Protein and Peptide Letters·2025Open Access
SHP2 genetic variants in NSML-associated RASopathies disrupt the PZR–IRX transcription factor signaling axis
Proceedings of the National Academy of Sciences·2025· 3 citedOpen Access
Complement factor I deficiency–associated neuroinflammatory disease among Old Order Amish
Journal of Allergy and Clinical Immunology·2025Open Access
Nickel binding to c-Src SH3 domain facilitates crystallization
2025Open Access
Abstract 3051 The C2 domain augments Ras GTPase Activating Protein catalytic activity
Journal of Biological Chemistry·2025Open Access
Novel heterozygous SPI1c.538C>T p.(Leu180Phe) variant causes PU.1 haploinsufficiency leading to agammaglobulinemia
Clinical Immunology·2025· 2 citedOpen Access
Cancer hotspot mutations rewire ERK2 specificity by selective exclusion of docking interactions
Journal of Biological Chemistry·2025· 3 citedOpen Access
The C2 domain augments Ras GTPase-activating protein catalytic activity
Proceedings of the National Academy of Sciences·2025· 3 citedOpen Access
The C2 domain augments Ras GTPase Activating Protein catalytic activity
2024Open Access
120 Treatable Acute Neuroinflammatory Disease Associated with Complement Factor I Loss-of-function in the Plain Community
Clinical Immunology·2024
Diverse p120RasGAP interactions with doubly phosphorylated partners EphB4, p190RhoGAP, and Dok1
Journal of Biological Chemistry·2023· 12 citedOpen Access
De novo variants implicate chromatin modification, transcriptional regulation, and retinoic acid signaling in syndromic craniosynostosis
The American Journal of Human Genetics·2023· 19 citedOpen Access
Structure Determination of SH2–Phosphopeptide Complexes by X-Ray Crystallography: The Example of p120RasGAP
Methods in molecular biology·2023· 1 citedOpen Access
Tandem engagement of phosphotyrosines by the dual SH2 domains of p120RasGAP
Structure·2022· 7 citedOpen Access
De novo mutations in the BMP signaling pathway in lambdoid craniosynostosis
Human Genetics·2022· 19 cited
SH3 domain regulation of RhoGAP activity: Crosstalk between p120RasGAP and DLC1 RhoGAP
Nature Communications·2022· 19 citedOpen Access
Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients
The Journal of Experimental Medicine·2021· 68 citedOpen Access
The pseudoGTPase group of pseudoenzymes
FEBS Journal·2020· 25 citedOpen Access
The GTPase-activating protein p120RasGAP has an evolutionarily conserved “FLVR-unique” SH2 domain
Journal of Biological Chemistry·2020· 13 citedOpen Access
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Frequent Co-authors

Titus J. Boggon(42), Richard P. Lifton(8), Rachel Jaber Chehayeb(7), David Calderwood(6), Kimberly J. Vish(5), Neil Romberg(4), Stevan R. Hubbard(3), Steven J. Burden(3), Murim Choi(3), Siming Zhao(3), Stefania Bellone(3), Emiliano Cocco(3), Natália Buza(3), Pei Hui(3), Antonella Ravaggi(3), Eliana Bignotti(3), Chiara Romani(3), Paola Todeschini(3), Laura Zanotti(3), Sërgio Pecorelli(3)